Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | BCR | P11274 | 2/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18753852 | 0.87 | POLB (0.45) | POLBMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL22422396 | 0.82 | PKM (0.60) | POLBMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL20192563 | 0.78 | PKLR (0.43) | POLBMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL2701180 | 0.77 | PKLR (0.64) | PKM | |
| SCHEMBL18753335 | 0.76 | LMNA (0.47) | POLBLRRK2TSHRCPS1 | |
| SCHEMBL18753827 | 0.74 | LRRK2 (0.43) | MEN1KMT2AALDH1A1MYCHPGD | |
| SCHEMBL19562201 | 0.74 | TSHR (0.50) | POLBALDH1A1L3MBTL1ABL1BCR | |
| SCHEMBL20750502 | 0.73 | POLB (0.50) | POLBALDH1A1L3MBTL1ABL1BCR | |
| SCHEMBL18753748 | 0.72 | RBP4 (0.47) | POLBMYCABL1BCRHPGD | |
| SCHEMBL8257601 | 0.71 | HPGD (0.54) | POLBMEN1KMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3708169-A1 | 2,3-DIHYDROBENZO[B][1,4]DIOXINE-6-SULFONAMIDE DERIVATIVES HAVING AN ANTICANCER ACTIVITY | Agios Pharmaceuticals, Inc. (US) | 2020-09-16 | — | — | EP | disclosed |