Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14639270 | 0.91 | CYP4F2 (0.39) | MAPK1MEN1KMT2APKMCYP4F2 | |
| SCHEMBL13292651 | 0.82 | MAPK1 (0.39) | MAPK1MEN1KMT2APKMCYP4F2 | |
| SCHEMBL7758971 | 0.81 | MEN1 (0.52) | MAPK1MEN1KMT2APKMCYP4F2 | |
| SCHEMBL1226141 | 0.81 | MAPK1 (0.39) | MAPK1MEN1KMT2APKMCYP4F2 | |
| SCHEMBL24241314 | 0.81 | POLB (0.46) | MAPK1MEN1KMT2APKMCYP4F2 | |
| SCHEMBL3251799 | 0.79 | CYP4F2 (0.53) | MAPK1MEN1KMT2APKMCYP4F2 | |
| SCHEMBL6067617 | 0.79 | MMP8 (0.42) | MAPK1MEN1KMT2APKMCYP4F2 | |
| SCHEMBL24565358 | 0.79 | MEN1 (0.38) | MAPK1MEN1KMT2APKMCYP4F2 | |
| SCHEMBL27351976 | 0.78 | FAAH (0.46) | MAPTALDH1A1LMNAHSD17B10ALOX15 | |
| SCHEMBL14533806 | 0.78 | MEN1 (0.42) | MEN1KMT2APKMCYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260102525-A1 | COXIB-DERIVED CONJUGATE COMPOUNDS AND METHODS OF USE THEREOF | SILBER B MICHAEL (US) | 2026-04-16 | — | — | US | disclosed |
| US-20250255992-A1 | COXIB-DERIVED CONJUGATE COMPOUNDS AND METHODS OF USE THEREOF | REILEY PHARMACEUTICALS INC (US) | 2025-08-14 | — | — | US | disclosed |
| US-20240358866-A1 | NSAID-DERIVED CONJUGATE COMPOUNDS FOR IMAGING | REILEY PHARMACEUTICALS INC (US) | 2024-10-31 | — | — | US | disclosed |
| WO-2024118818-A1 | NSAID-DERIVED CONJUGATE COMPOUNDS FOR IMAGING | Reiley Pharmaceuticals, Inc. (US) | 2024-06-06 | — | — | WO | disclosed |
| EP-4225384-A1 | COXIB-DERIVED CONJUGATE COMPOUNDS AND METHODS OF USE THEREOF | Reiley Pharmaceuticals, Inc. (US) | 2023-08-16 | — | — | EP | disclosed |
| CN-116406368-A | Conjugated compounds derived from sibs and methods of use thereof | 赖利制药公司 | 2023-07-07 | — | — | CN | disclosed |
| US-20220133918-A1 | COXIB-DERIVED CONJUGATE COMPOUNDS AND METHODS OF USE THEREOF | Reiley Pharmaceuticals, Inc. | 2022-05-05 | — | — | US | disclosed |
| US-20220133918-A1 | COXIB-DERIVED CONJUGATE COMPOUNDS AND METHODS OF USE THEREOF | Reiley Pharmaceuticals, Inc. | 2022-05-05 | — | — | US | disclosed |
| US-7947683-B2 | 3-(1,2,4-triazol-3-ylalkyl) azabicyclo (3.1.0) hexane derivatives as modulators of dopamine D3 receptors | GLAXO GROUP LIMTED (GB) | 2011-05-24 | — | — | US | disclosed |
| US-7947683-B2 | 3-(1,2,4-triazol-3-ylalkyl) azabicyclo (3.1.0) hexane derivatives as modulators of dopamine D3 receptors | GLAXO GROUP LIMTED (GB) | 2011-05-24 | — | — | US | disclosed |
| US-7947683-B2 | 3-(1,2,4-triazol-3-ylalkyl) azabicyclo (3.1.0) hexane derivatives as modulators of dopamine D3 receptors | GLAXO GROUP LIMTED (GB) | 2011-05-24 | — | — | US | disclosed |
| US-20090124629-A1 | 3-(1,2,4-TRIAZOL-3YLALKYL) AZABRICLO (3.1.0) HEXANE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-05-14 | — | — | US | disclosed |
| US-20090124629-A1 | 3-(1,2,4-TRIAZOL-3YLALKYL) AZABRICLO (3.1.0) HEXANE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-05-14 | — | — | US | disclosed |
| US-20090124629-A1 | 3-(1,2,4-TRIAZOL-3YLALKYL) AZABRICLO (3.1.0) HEXANE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-05-14 | — | — | US | disclosed |
| EP-1869017-A1 | 3- (1,2,4-TRIAZOL-3YLALKYL) AZABRICLO (3.1.0) HEXANE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006108701-A1 | 3- (1,2,4-TRIAZOL-3YLALKYL) AZABRICLO (3.1.0) HEXANE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2006-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124629-A1 | 3-(1,2,4-TRIAZOL-3YLALKYL) AZABRICLO (3.1.0) HEXANE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | DRD3, HTR3C, TACR2 | MAPK1 1400/4885MEN1 3837/4885KMT2A 4062/4885 |
| US-20250255992-A1 | COXIB-DERIVED CONJUGATE COMPOUNDS AND METHODS OF USE THEREOF | PTGES2, PTGES, OPRK1 | MAPK1 1538/4885MEN1 4012/4885KMT2A 3427/4885 |
| US-20260102525-A1 | COXIB-DERIVED CONJUGATE COMPOUNDS AND METHODS OF USE THEREOF | OPRK1, OPRD1, OPRM1 | MAPK1 1027/4885MEN1 1470/4885KMT2A 2292/4885 |
| US-20220133918-A1 | COXIB-DERIVED CONJUGATE COMPOUNDS AND METHODS OF USE THEREOF | PTGES2, PTGES, OPRK1 | MAPK1 1538/4885MEN1 4012/4885KMT2A 3427/4885 |
| US-20240358866-A1 | NSAID-DERIVED CONJUGATE COMPOUNDS FOR IMAGING | PTGES2, PTGS2, PTGES | MAPK1 1753/4885MEN1 3431/4885KMT2A 3946/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.