Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of 2,2'-Dithiodiethanesulfonic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.31 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | HBB | P68871 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.36 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2,2'-Dithiodiethanesulfonic Acid SCHEMBL835029 | 1.00 | KDM4E (0.48) | KDM4EMAPTALOX15ALDH1A1TSHR | |
| 2,2'-Dithiodiethanesulfonic Acid SCHEMBL835873 | 0.97 | KDM4E (0.46) | KDM4EMAPTALOX15ALDH1A1TSHR | |
| 2,2'-Dithiodiethanesulfonic Acid SCHEMBL8403162 | 0.97 | KDM4E (0.46) | KDM4EMAPTALOX15ALDH1A1TSHR | |
| 2,2'-Dithiodiethanesulfonic Acid SCHEMBL835186 | 0.94 | KDM4E (0.41) | KDM4EMAPTALOX15ALDH1A1TSHR | |
| 2,2'-Dithiodiethanesulfonic Acid SCHEMBL835426 | 0.94 | KDM4E (0.41) | KDM4EMAPTALOX15ALDH1A1TSHR | |
| 2,2'-Dithiodiethanesulfonic Acid SCHEMBL837033 | 0.94 | KDM4E (0.41) | KDM4EMAPTALOX15ALDH1A1TSHR | |
| 2,2'-Dithiodiethanesulfonic Acid SCHEMBL834471 | 0.94 | KDM4E (0.41) | KDM4EMAPTALOX15ALDH1A1TSHR | |
| SCHEMBL8459850 | 0.87 | BBOX1 (0.39) | KDM4EMAPTALOX15ALDH1A1TSHR | |
| 2,2'-Dithiodiethanesulfonic Acid SCHEMBL7050821 | 0.87 | KDM4E (0.39) | KDM4EMAPTALOX15ALDH1A1TSHR | |
| 2,2'-Dithiodiethanesulfonic Acid SCHEMBL834581 | 0.87 | KDM4E (0.39) | KDM4EMAPTALOX15ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4082 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025137692-A1 | COMBINATION OF DIMESNA AND PEMETREXED TO TREAT NON-SMALL CELL LUNG CANCER (NSCLC) | LANTERN PHARMA INC. (US) | 2025-06-26 | — | — | WO | claimed |
| US-20250084059-A1 | CRYSTALLINE FORMS OF C21H22Cl2N4O2 | BIOMED VALLEY DISCOVERIES INC (US) | 2025-03-13 | — | — | US | claimed |
| CN-118987015-A | Application of antisense oligonucleotide in preparation of medicine for treating breast cancer | 北京悦康科创医药科技股份有限公司 | 2024-11-22 | — | — | CN | claimed |
| CN-117815156-A | Green tea polyphenol repair cream and preparation method thereof | 福州萍晴日用化妆品有限公司 | 2024-04-05 | — | — | CN | claimed |
| CN-117813005-A | Fungicidal compositions | 先正达农作物保护股份公司 | 2024-04-02 | — | — | CN | claimed |
| CN-114755326-B | Detection method of difenoconazole in hydroxypropyl methylcellulose | 浙江省化工产品质量检验站有限公司 | 2024-02-02 | — | — | CN | claimed |
| CN-117482461-A | Fe/Na 2 SO 3 Method for efficiently degrading metallocene powder by mechanical grinding agent | 浙江工业大学 | 2024-02-02 | — | — | CN | claimed |
| CN-117396194-A | Targeted therapeutic lipid nanoparticles and methods of use | 宾夕法尼亚大学理事会 | 2024-01-12 | — | — | CN | claimed |
| US-20230220481-A1 | Method for Determining Sensitivity to 2,2'-Dithio-bis-Ethane Sulfonate | LANTERN PHARMA INC. | 2023-07-13 | — | — | US | claimed |
| US-20230210794-A1 | Increasing Cancer Patient Survival Time by Administration of Dithio-Containing Compounds | LANTERN PHARMA INC. (US) | 2023-07-06 | — | — | US | claimed |
| EP-0957920-B1 | REDUCING TOXIC EFFECTS OF CARBOPLATIN USING DITHIOETHERS | BIONUMERIK PHARMACEUTICALS INC (US) | 2001-12-19 | — | — | EP | claimed |
| EP-0934261-B1 | PROCESS FOR PRODUCING DITHIOBIS-ALKANESULFONATES AND PHOSPHONATES | BIONUMERIK PHARMACEUTICALS INC (US) | 2001-10-31 | — | — | EP | claimed |
| JP-2001501219-A | — | — | 2001-01-30 | — | — | JP | claimed |
| US-6037336-A | ADMINISTERING A DISULFIDE SUFLONATE OR PHOSPHONATE WITH CARBOPLATIN (ANTICANCER AGENT) TO REDUCE SIDE EFFECTS | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2000-03-14 | — | — | US | claimed |
| EP-0957920-A1 | REDUCING TOXIC EFFECTS OF CARBOPLATIN USING DITHIOETHERS | BIONUMERIK PHARMACEUTICALS, INC. (US) | 1999-11-24 | — | — | EP | claimed |
| CN-1230887-A | Reducing toxic effects of carboplatin using dithioethers | BIONUMERIK PHARMACEUTICALS INC (US) | 1999-10-06 | — | — | CN | claimed |
| EP-0934261-A1 | PROCESS FOR PRODUCING MERCAPTOALKANESULFONATES AND PHOSPHONATES AND DERIVATIVES THEREOF | BIONUMERIK PHARMACEUTICALS, INC. (US) | 1999-08-11 | — | — | EP | claimed |
| US-5902610-A | ADMINISTERING WITH OR WITHOUT CISPLATIN IN THE SAME FORMULATION, TO REDUCE TOXIC SIDE EFFECTS OF CISPLATIN IN CANCER THERAPY AND POTENTIATE ITS ANTITUMOR ACTIVITY | BIONUMERIK PHARMACEUTICALS, INC. (US) | 1999-05-11 | — | — | US | claimed |
| WO-1998014426-A1 | PROCESS FOR PRODUCING MERCAPTOALKANESULFONATES AND PHOSPHONATES AND DERIVATIVES THEREOF | BIONUMERIK PHARMACEUTICALS, INC. (US) | 1998-04-09 | — | — | WO | claimed |
| WO-1998011898-A1 | REDUCING TOXIC EFFECTS OF CARBOPLATIN USING DITHIOETHERS | BIONUMERIK PHARMACEUTICALS, INC. (US) | 1998-03-26 | — | — | WO | claimed |