Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HBB | P68871 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL133153 | 0.82 | — | — | |
| Tromethamine SCHEMBL8331224 | 0.79 | LMNA (0.59) | ALDH1A1TDP1LMNAMEN1KMT2A | |
| SCHEMBL28821908 | 0.79 | — | — | |
| SCHEMBL1446235 | 0.79 | — | — | |
| SCHEMBL30442526 | 0.79 | — | — | |
| Tromethamine SCHEMBL11444665 | 0.73 | GALR3 (0.37) | ALDH1A1TDP1LMNAMEN1KMT2A | |
| Dimethyl Sulfoxide SCHEMBL28115041 | 0.70 | ALDH1A1 (0.74) | ALDH1A1TDP1LMNAMEN1KMT2A | |
| Tromethamine SCHEMBL5429905 | 0.69 | MEN1 (0.83) | ALDH1A1LMNAMEN1KMT2A | |
| Tromethamine SCHEMBL975 | 0.69 | — | — | |
| Tromethamine SCHEMBL3696191 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4680201-A1 | COMPOSITIONS AND USES THEREOF FOR STABILIZATION OF BLOOD SAMPLE COMPONENTS | Streck LLC (US) | 2026-01-21 | — | — | EP | claimed |
| WO-2024192232-A9 | COMPOSITIONS AND USES THEREOF FOR STABILIZATION OF BLOOD SAMPLE COMPONENTS | STRECK LLC (US) | 2025-02-06 | — | — | WO | claimed |
| WO-2024192232-A1 | COMPOSITIONS AND USES THEREOF FOR STABILIZATION OF BLOOD SAMPLE COMPONENTS | STRECK LLC (US) | 2024-09-19 | — | — | WO | claimed |
| EP-2498613-A1 | BIOCIDAL COMPOSITIONS AND METHODS OF USE | Dow Global Technologies LLC (US) | 2012-09-19 | — | — | EP | claimed |
| WO-2011059532-A1 | BIOCIDAL COMPOSITIONS AND METHODS OF USE | DOW GLOBAL TECHNOLOGIES INC. (US) | 2011-05-19 | — | — | WO | claimed |
| WO-2010138420-A2 | GLUTARALDEHYDE BASED BIOCIDAL COMPOSITIONS AND METHODS OF USE | DOW GLOBAL TECHNOLOGIES INC. (US) | 2010-12-02 | — | — | WO | claimed |
| EP-1639184-A1 | FABRIC CARE COMPOSITIONS FOR LIPOPHILIC FLUID SYSTEMS INCORPORATING AN ANTIMICROBIAL AGENT | THE PROCTER & GAMBLE COMPANY (US) | 2006-03-29 | — | — | EP | claimed |
| EP-1639185-A1 | FABRIC CARE COMPOSITIONS FOR LIPOPHILIC FLUID SYSTEMS CONTAINING AN ANTIMICROBIAL AGENT | The Procter & Gamble Company (US) | 2006-03-29 | — | — | EP | claimed |
| WO-2005003436-A1 | FABRIC CARE COMPOSITIONS FOR LIPOPHILIC FLUID SYSTEMS INCORPORATING AN ANTIMICROBIAL AGENT | THE PROCTER & GAMBLE COMPANY (US) | 2005-01-13 | — | — | WO | claimed |
| WO-2005003437-A1 | FABRIC CARE COMPOSITIONS FOR LIPOPHILIC FLUID SYSTEMS CONTAINING AN ANTIMICROBIAL AGENT | THE PROCTER & GAMBLE COMPANY (US) | 2005-01-13 | — | — | WO | claimed |
| US-20040261195-A1 | Fabric care compositions for lipophilic fluid systems containing an antimicrobial agent | THE PROCTER & GAMBLE COMPANY | 2004-12-30 | — | — | US | claimed |
| US-20040261196-A1 | Fabric care compositions for lipophilic fluid systems incorporating an antimicrobial agent | THE PROCTER & GAMBLE COMPANY | 2004-12-30 | — | — | US | claimed |
| EP-0004217-A1 | Process for the bactericidal and biostatical treatment of a polluted medium | SOCIETE CHIMIQUE DE LA GRANDE PAROISSE, AZOTE ET PRODUITS CHIMIQUES (FR) | 1979-09-19 | — | — | EP | claimed |
| CN-114479673-B | Polishing slurry composition | 凯斯科技股份有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-114479673-A | Polishing slurry composition | 凯斯科技股份有限公司 | 2022-05-13 | — | — | CN | disclosed |
| EP-3957494-A1 | RUBBER REINFORCEMENT ADHESIVE | The Goodyear Tire & Rubber Company (US) | 2022-02-23 | — | — | EP | disclosed |
| EP-0688321-A1 | N-(BETA-BRANCHED ALKYL)-1,2-BENZISOTHIAZOLIN-3-ONES, THEIR PREPARATION AND USE AS INDUSTRIAL BIOCIDES | ZENECA LTD (GB) | 1995-12-27 | — | — | EP | disclosed |
| EP-0348223-B1 | Novel process for the preparation of serinol | ANGUS CHEMICAL (US) | 1995-06-07 | — | — | EP | disclosed |
| WO-1994020479-A1 | N-(BETA-BRANCHED ALKYL)-1,2-BENZISOTHIAZOLIN-3-ONES, THEIR PREPARATION AND USE AS INDUSTRIAL BIOCIDES | ZENECA LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |
| EP-0348223-A2 | Novel process for the preparation of serinol | ANGUS CHEMICAL COMPANY (US) | 1989-12-27 | — | — | EP | disclosed |