Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 4/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | RGS4 | P49798 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7830939 | 0.81 | MGLL (0.53) | MGLLHSP90AA1POLBKMT2AFAAH | |
| SCHEMBL20760615 | 0.81 | MGLL (0.53) | MGLLMAPK1KMT2AFAAHMEN1 | |
| SCHEMBL9725345 | 0.81 | FAAH (0.39) | MGLLMAPK1NPSR1TDP1ESR2 | |
| SCHEMBL1163961 | 0.80 | MGLL (0.50) | MGLLPKMMAPK1NPSR1TDP1 | |
| SCHEMBL8443563 | 0.77 | MGLL (0.53) | MGLLHSP90AA1PKMMAPK1NPSR1 | |
| SCHEMBL20760789 | 0.77 | RGS4 (0.40) | MGLLNPSR1KMT2AFAAHMEN1 | |
| SCHEMBL20760459 | 0.76 | NSD2 (0.46) | POLBKMT2AMEN1RGS4 | |
| SCHEMBL8055826 | 0.74 | HSP90AA1 (0.60) | MGLLHSP90AA1MAPK1NPSR1TDP1 | |
| SCHEMBL18942348 | 0.73 | ALDH1A1 (0.45) | PKMMAPK1NPSR1ESR1ESR2 | |
| SCHEMBL18942745 | 0.73 | KMT2A (0.56) | MGLLHSP90AA1PKMPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110914240-B | Norbornenone compounds releasing carbon monoxide | 奥塔哥创新有限公司 | 2024-02-20 | — | — | CN | disclosed |
| EP-3383846-B1 | CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS | OTAGO INNOVATION LTD (NZ) | 2022-06-22 | — | — | EP | disclosed |
| US-11072584-B2 | Carbon monoxide releasing norbornenone compounds | OTAGO INNOVATION LIMITED (NZ) | 2021-07-27 | — | — | US | disclosed |
| US-11072584-B2 | Carbon monoxide releasing norbornenone compounds | OTAGO INNOVATION LIMITED (NZ) | 2021-07-27 | — | — | US | disclosed |
| US-20200109115-A1 | CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS | AUCKLAND UNISERVICES LIMITED (NZ) | 2020-04-09 | — | — | US | disclosed |
| US-20200109115-A1 | CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS | AUCKLAND UNISERVICES LIMITED (NZ) | 2020-04-09 | — | — | US | disclosed |
| CN-110914240-A | Norbornene ketone compounds releasing carbon monoxide | 奥塔哥创新有限公司 | 2020-03-24 | — | — | CN | disclosed |
| US-20180346420-A1 | CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS | UNIVERSITY OF OTAGO (NZ) | 2018-12-06 | — | — | US | disclosed |
| EP-3383846-A1 | CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS | Sammut, Ivan Andrew (NZ) | 2018-10-10 | — | — | EP | disclosed |
| WO-2017095237-A1 | CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS | SAMMUT IVAN ANDREW (NZ) | 2017-06-08 | — | — | WO | disclosed |
| WO-2017095237-A1 | CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS | SAMMUT IVAN ANDREW (NZ) | 2017-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200109115-A1 | CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS | HMOX1, MB, NOS2 | MGLL 4352/4885HSP90AA1 924/4885PKM 3219/4885 |
| US-20180346420-A1 | CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS | HMOX1, MB, NOS2 | MGLL 4352/4885HSP90AA1 924/4885PKM 3219/4885 |
| US-11072584-B2 | Carbon monoxide releasing norbornenone compounds | HMOX1, MB, NOS2 | MGLL 4352/4885HSP90AA1 924/4885PKM 3219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.