Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TYMS | P04818 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.43 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18976336 | 0.84 | ALDH1A1 (0.56) | MAPTKMT2AALDH1A1RAB9AHPGD | |
| SCHEMBL6230784 | 0.74 | ALDH1A1 (0.64) | MAPTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL20581440 | 0.74 | HRH4 (0.44) | MAPTALDH1A1RAB9AHPGDPOLB | |
| SCHEMBL20581201 | 0.72 | HRH4 (0.41) | MAPTALDH1A1RAB9AHPGDPOLB | |
| SCHEMBL3145322 | 0.72 | CA12 (0.62) | MAPTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL23258256 | 0.71 | MMP2 (0.57) | MAPTMEN1KMT2ARAB9AMMP2 | |
| SCHEMBL20580941 | 0.70 | JAK1 (0.41) | MAPTALDH1A1RAB9AHPGDACHE | |
| SCHEMBL18976466 | 0.70 | HRAS (0.41) | MAPTALDH1A1RAB9AHPGDF2 | |
| SCHEMBL8764667 | 0.69 | PTGS2 (0.42) | MAPTMEN1KMT2ARAB9AMMP2 | |
| SCHEMBL18976320 | 0.69 | RAB9A (0.60) | MAPTALDH1A1RAB9AHPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10640507-B2 | PBD antibacterial agents | KING'S COLLEGE LONDON (GB) | 2020-05-05 | — | — | US | disclosed |
| US-10640507-B2 | PBD antibacterial agents | KING'S COLLEGE LONDON (GB) | 2020-05-05 | — | — | US | disclosed |
| US-20180354958-A1 | PBD ANTIBACTERIAL AGENTS | Secretary of State for Health and Social Care (GB) | 2018-12-13 | — | — | US | disclosed |
| WO-2017098257-A1 | PBD ANTIBACTERIAL AGENTS | KING'S COLLEGE LONDON (GB) | 2017-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10640507-B2 | PBD antibacterial agents | OPRD1, XDH, SBDS | MAPT 4438/4885MEN1 3217/4885KMT2A 3038/4885 |
| US-20180354958-A1 | PBD ANTIBACTERIAL AGENTS | OPRD1, XDH, SBDS | MAPT 4438/4885MEN1 3217/4885KMT2A 3038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.