Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.40 |
| ▸ | GRM8 | O00222 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL1301472 | 1.00 | CA1 (0.46) | CA1BBOX1GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL82753 | 0.98 | CA1 (0.48) | CA1BBOX1GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL757896 | 0.98 | CA1 (0.48) | CA1BBOX1GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL82750 | 0.98 | CA1 (0.48) | CA1BBOX1GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL7068284 | 0.98 | CA1 (0.48) | CA1BBOX1GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL23611029 | 0.98 | CA1 (0.48) | CA1BBOX1GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL7611844 | 0.98 | CA1 (0.48) | CA1BBOX1GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL1518007 | 0.95 | CA1 (0.50) | CA1BBOX1GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL11742432 | 0.95 | CA1 (0.46) | CA1BBOX1GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL2853218 | 0.95 | CA1 (0.50) | CA1BBOX1GRM8GRM6GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3395862-B1 | RESIN COMPOSITION PELLETS | MITSUBISHI CHEM CORP (JP) | 2023-05-10 | — | — | EP | disclosed |
| US-10358533-B2 | Resin composition pellet | MITSUBISHI CHEMICAL CORPORATION (JP) | 2019-07-23 | — | — | US | disclosed |
| US-20180371179-A1 | RESIN COMPOSITION PELLET | THE NIPPON SYNTHETIC CHEMICAL INDUSTRY CO., LTD. (JP) | 2018-12-27 | — | — | US | disclosed |
| EP-3395862-A1 | RESIN COMPOSITION PELLETS | The Nippon Synthetic Chemical Industry Co., Ltd. (JP) | 2018-10-31 | — | — | EP | disclosed |
| EP-2845881-B1 | RESIN COMPOSITION, MELT FORMED ARTICLE, MULTILAYER STRUCTURE, AND PROCESS FOR PRODUCING RESIN COMPOSITION | NIPPON SYNTHETIC CHEM IND CO LTD (JP) | 2018-04-11 | — | — | EP | disclosed |
| EP-2322578-B1 | RESIN COMPOSITION, MELT FORMED ARTICLE, MULTILAYER STRUCTURE, AND PROCESS FOR PRODUCING RESIN COMPOSITION | NIPPON SYNTHETIC CHEM IND CO LTD (JP) | 2017-09-20 | — | — | EP | disclosed |
| US-9376545-B2 | Resin composition, melt-formed article, multilayer structure, and process for producing resin composition | THE NIPPON SYNTHETIC CHEMICAL INDUSTRY CO., LTD. (JP) | 2016-06-28 | — | — | US | disclosed |
| EP-2845881-A1 | Resin composition, melt formed article, multilayer structure, and process for producing resin composition | The Nippon Synthetic Chemical Industry Co., Ltd. (JP) | 2015-03-11 | — | — | EP | disclosed |
| US-20110135950-A1 | RESIN COMPOSITION, MELT-FORMED ARTICLE, MULTILAYER STRUCTURE, AND PROCESS FOR PRODUCING RESIN COMPOSITION | THE NIPPON SYNTHETIC CHEMICAL INDUSTRY CO., LTD., (JP) | 2011-06-09 | — | — | US | disclosed |
| EP-2322578-A1 | RESIN COMPOSITION, MELT-MOLDED ARTICLE, MULTI-LAYERED STRUCTURE, AND PROCESS FOR PRODUCTION OF RESIN COMPOSITION | The Nippon Synthetic Chemical Industry Co., Ltd. (JP) | 2011-05-18 | — | — | EP | disclosed |