Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.42 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | GRM8 | O00222 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL2853212 | 1.00 | CA1 (0.50) | CA1FOLH1BBOX1CA2GRM8 | |
| D-Glutamate SCHEMBL28385660 | 0.98 | CA1 (0.48) | CA1FOLH1BBOX1CA2GRM8 | |
| D-Glutamate SCHEMBL541429 | 0.98 | CA1 (0.52) | CA1FOLH1BBOX1CA2GRM8 | |
| D-Glutamate SCHEMBL18880 | 0.98 | CA1 (0.52) | CA1FOLH1BBOX1CA2GRM8 | |
| D-Glutamate SCHEMBL82750 | 0.98 | CA1 (0.48) | CA1FOLH1BBOX1CA2GRM8 | |
| D-Glutamate SCHEMBL23611029 | 0.98 | CA1 (0.48) | CA1FOLH1BBOX1CA2GRM8 | |
| D-Glutamate SCHEMBL330961 | 0.98 | CA1 (0.52) | CA1FOLH1BBOX1CA2GRM8 | |
| D-Glutamate SCHEMBL16335 | 0.98 | CA1 (0.52) | CA1FOLH1BBOX1CA2GRM8 | |
| D-Glutamate SCHEMBL82753 | 0.98 | CA1 (0.48) | CA1FOLH1BBOX1CA2GRM8 | |
| D-Glutamate SCHEMBL7068284 | 0.98 | CA1 (0.48) | CA1FOLH1BBOX1CA2GRM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118715314-A | Production of colored fungal mycelia | 玛仕莱布斯有限公司 | 2024-09-27 | — | — | CN | disclosed |
| CN-112125821-B | Aqueous solution containing N-long-chain acyl acidic amino acid and/or salt thereof and method for producing same | 味之素株式会社 | 2024-02-20 | — | — | CN | disclosed |
| CN-114762742-A | Extracorporeal blood medication system | 张勇 | 2022-07-19 | — | — | CN | disclosed |
| EP-0843818-B2 | LAWSONIA INTRACELLULARIS CULTIVATION, ANTI-LAWSONIA INTRACELLULARIS VACCINES AND DIAGNOSTIC AGENTS | BOEHRINGER INGELHEIM VETMEDICA INC (US) | 2018-12-19 | — | — | EP | disclosed |
| EP-1403643-B2 | Lawsonia intracellularis cultivation, anti-lawsonia intracelluaris vaccines and diagnostic agents | BOEHRINGER INGELHEIM VETMEDICA INC (US) | 2018-10-03 | — | — | EP | disclosed |
| EP-2199795-B1 | Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents | BOEHRINGER INGELHEIM VETMED (US) | 2016-03-30 | — | — | EP | disclosed |
| EP-1645567-B2 | Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents | BOEHRINGER INGELHEIM VETMED (US) | 2016-01-06 | — | — | EP | disclosed |
| CN-104800841-A | Inactivated vaccine for abortion chlamydia of yaks and preparation method of inactivated vaccine | LANZHOU VETERINARY RES INST CAAS | 2015-07-29 | — | — | CN | disclosed |
| EP-1655607-B1 | Lawsonia intracellularis cultivation, anti-lawsonia intracellularis vaccines and diagnostic agents | BOEHRINGER INGELHEIM VETMED (US) | 2015-05-13 | — | — | EP | disclosed |
| CN-1519311-B | Lawsonia intracellularis cultivation, anti-lawsonia intracelluaris vaccines and diagnostic agents | NOBL LAB INC | 2013-03-13 | — | — | CN | disclosed |
| EP-0843818-B1 | LAWSONIA INTRACELLULARIS CULTIVATION, ANTI-LAWSONIA INTRACELLULARIS VACCINES AND DIAGNOSTIC AGENTS | BOEHRINGER INGELHEIM VETMED (US) | 2005-02-09 | — | — | EP | disclosed |
| CN-1519311-A | Lawsonia intracellularis cultivation, anti-lawsonia intracelluaris vaccines and diagnostic agents | 诺博实验室股份有限公司 | 2004-08-11 | — | — | CN | disclosed |
| EP-1403643-A1 | Lawsonia intracellularis cultivation, anti-lawsonia intracelluaris vaccines and diagnostic agents | Boehringer Ingelheim Vetmedica, Inc. (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-0843818-A4 | LAWSONIA INTRACELLULARIS CULTIVATION, ANTI-LAWSONIA INTRACELLULARIS VACCINES AND DIAGNOSTIC AGENTS | BOEHRINGER INGELHEIM NOBL LAB (US) | 2002-02-06 | — | — | EP | disclosed |
| US-5885823-A | BACTERIA STRAIN ATCC NO.55783 ARE INCUBATED IN AN OXYGEN CONCENTRATION OF FROM ABOUT 0 PERCENT TO ABOUT 18 PERCENT, AGITATING THE BACTERIA IN SUSPENSION; VETERINARY MEDICINE | NOBL LABORATORIES, INC. (US) | 1999-03-23 | — | — | US | disclosed |
| EP-0843818-A1 | LAWSONIA INTRACELLULARIS CULTIVATION, ANTI-LAWSONIA INTRACELLULARIS VACCINES AND DIAGNOSTIC AGENTS | Boehringer Ingelheim/Nobl Laboratories, Inc. (US) | 1998-05-27 | — | — | EP | disclosed |
| CN-1181898-A | Gourmet powder | XIE YONG (CN) | 1998-05-20 | — | — | CN | disclosed |
| US-5714375-A | INCUBATING INFECTED CELLS IN A REDUCED OXYGEN CONCENTRATION AND MAINTAINING INFECTED CELL IN SUSPENSION BY AGITATION FOR PREFERENTIAL TIME TO INCREASE THE PRODUCTION, AND CULTURING AT LEAST A PORTION OF THE BACTERIA | NOBL LABORATORIES, INC. (US) | 1998-02-03 | — | — | US | disclosed |
| CN-1167146-A | Lawsonia intracellularis culture, vaccine and diagnostic reagent against the same | NOBL LAB INC (US) | 1997-12-10 | — | — | CN | disclosed |
| WO-1996039629-A1 | LAWSONIA INTRACELLULARIS CULTIVATION, ANTI-LAWSONIA INTRACELLULARIS VACCINES AND DIAGNOSTIC AGENTS | BOEHRINGER INGELHEIM/NOBL LABORATORIES, INC. (US) | 1996-12-12 | — | — | WO | disclosed |