Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19061876 | 0.93 | GFER (0.47) | GFERKDM4ENPC1RAB9APKM | |
| SCHEMBL19019921 | 0.90 | PKM (0.48) | GFERKDM4ENPC1RAB9APKM | |
| SCHEMBL19019915 | 0.89 | TRPV6 (0.61) | GFERKDM4ENPC1PKMTRPV6 | |
| SCHEMBL19061885 | 0.86 | MEN1 (0.52) | KDM4EPKMTRPV6LMNAALDH1A1 | |
| SCHEMBL19062034 | 0.85 | GFER (0.44) | GFERKDM4ENPC1RAB9AMAPT | |
| SCHEMBL19061594 | 0.85 | CYP3A4 (0.47) | GFERKDM4ENPC1RAB9APKM | |
| SCHEMBL19061887 | 0.84 | L3MBTL1 (0.51) | RAB9APKMMAPTLMNADAO | |
| SCHEMBL19019917 | 0.84 | TDP1 (0.46) | KDM4EPKMTRPV6POLBALDH1A1 | |
| SCHEMBL19061459 | 0.84 | RAB9A (0.46) | GFERKDM4ENPC1RAB9APKM | |
| SCHEMBL19061951 | 0.84 | NPC1 (0.46) | GFERNPC1RAB9APOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184514-A1 | AUTOPHAGY INHIBITORS | Deutsches Krebsforschungszentrum (DE) | 2017-06-28 | — | — | EP | disclosed |