Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PLD2 | O14939 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19019883 | 0.92 | LMNA (0.45) | HDAC2HDAC8HDAC6PLD2DRD4 | |
| SCHEMBL19061951 | 0.84 | NPC1 (0.46) | ALDH1A1POLBMEN1LMNAKMT2A | |
| SCHEMBL19019897 | 0.80 | KMT2A (0.36) | ALDH1A1MAPTMEN1KMT2AHSD17B10 | |
| SCHEMBL19019916 | 0.80 | KMT2A (0.36) | ALDH1A1MAPTMEN1KMT2AHSD17B10 | |
| SCHEMBL19061885 | 0.77 | MEN1 (0.52) | ALDH1A1HTTMEN1LMNAKMT2A | |
| SCHEMBL19061881 | 0.76 | TP53 (0.47) | ALDH1A1POLBMAPTLMNATSHR | |
| SCHEMBL19019907 | 0.76 | LMNA (0.41) | HDAC2HDAC8HDAC6DRD4ALDH1A1 | |
| SCHEMBL19061887 | 0.76 | L3MBTL1 (0.51) | DRD4MAPTMEN1LMNAKMT2A | |
| SCHEMBL19061459 | 0.76 | RAB9A (0.46) | ALDH1A1POLBMAPTMEN1LMNA | |
| SCHEMBL19019917 | 0.76 | TDP1 (0.46) | ALDH1A1POLBHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184514-A1 | AUTOPHAGY INHIBITORS | Deutsches Krebsforschungszentrum (DE) | 2017-06-28 | — | — | EP | disclosed |