Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | PDE6D | O43924 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19019901 | 0.92 | HDAC2 (0.41) | LMNAPOLBHDAC2HDAC8HDAC6 | |
| SCHEMBL19061881 | 0.83 | TP53 (0.47) | LMNASMN1; SMN2POLBHPGDGLA | |
| SCHEMBL19019907 | 0.83 | LMNA (0.41) | LMNASMN1; SMN2POLBHPGDGLA | |
| SCHEMBL19061883 | 0.79 | MEN1 (0.48) | LMNASMN1; SMN2POLBHPGDGLA | |
| SCHEMBL19019922 | 0.78 | MAPK1 (0.50) | SMN1; SMN2POLBALDH1A1HTTMEN1 | |
| SCHEMBL19061740 | 0.78 | NPC1 (0.46) | LMNAPOLBALDH1A1HTTMEN1 | |
| SCHEMBL19019834 | 0.77 | PLA2G7 (0.47) | SMN1; SMN2POLBALDH1A1DRD4MEN1 | |
| SCHEMBL19019870 | 0.77 | CHRNB2 (0.43) | LMNASMN1; SMN2POLBHPGDRXFP1 | |
| SCHEMBL14286352 | 0.77 | OPRK1 (0.48) | LMNASMN1; SMN2POLBMEN1MAPT | |
| SCHEMBL19061951 | 0.76 | NPC1 (0.46) | LMNASMN1; SMN2POLBALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184514-A1 | AUTOPHAGY INHIBITORS | Deutsches Krebsforschungszentrum (DE) | 2017-06-28 | — | — | EP | disclosed |