Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19019922 | 0.89 | MAPK1 (0.50) | KMT2AMAPK1GAAPOLBKDM4E | |
| SCHEMBL19061881 | 0.88 | TP53 (0.47) | LMNAMAPK1HPGDPOLBALDH1A1 | |
| SCHEMBL19061883 | 0.85 | MEN1 (0.48) | LMNAKMT2AMAPK1GAAHPGD | |
| SCHEMBL19019870 | 0.85 | CHRNB2 (0.43) | LMNAKMT2AMAPK1HPGDPOLB | |
| SCHEMBL19019834 | 0.85 | PLA2G7 (0.47) | KMT2AMAPK1POLBALDH1A1MEN1 | |
| SCHEMBL14286352 | 0.85 | OPRK1 (0.48) | LMNAKMT2AMAPK1POLBMEN1 | |
| SCHEMBL19019883 | 0.83 | LMNA (0.45) | LMNAKMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL19019921 | 0.82 | PKM (0.48) | LMNAKMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL19061740 | 0.82 | NPC1 (0.46) | LMNAKMT2AMAPK1POLBALDH1A1 | |
| SCHEMBL19019919 | 0.82 | HIF1A (0.47) | KMT2AMAPK1HIF1AEPAS1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184514-A1 | AUTOPHAGY INHIBITORS | Deutsches Krebsforschungszentrum (DE) | 2017-06-28 | — | — | EP | disclosed |