Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19061951 | 0.91 | NPC1 (0.46) | TP53SMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL19019907 | 0.88 | LMNA (0.41) | TP53SMN1; SMN2HPGDALDH1A1POLB | |
| SCHEMBL19061595 | 0.86 | ALDH1A1 (0.46) | TP53SMN1; SMN2RAB9ATSHRHPGD | |
| SCHEMBL19019921 | 0.85 | PKM (0.48) | TP53SMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL19061883 | 0.84 | MEN1 (0.48) | SMN1; SMN2NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL19019922 | 0.83 | MAPK1 (0.50) | SMN1; SMN2RAB9AALDH1A1POLBMAPK1 | |
| SCHEMBL19019883 | 0.83 | LMNA (0.45) | TP53SMN1; SMN2HPGDALDH1A1POLB | |
| SCHEMBL19019870 | 0.81 | CHRNB2 (0.43) | TP53SMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL14286352 | 0.81 | OPRK1 (0.48) | SMN1; SMN2POLBMAPK1MAPTLMNA | |
| SCHEMBL19019834 | 0.81 | PLA2G7 (0.47) | TP53SMN1; SMN2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184514-A1 | AUTOPHAGY INHIBITORS | Deutsches Krebsforschungszentrum (DE) | 2017-06-28 | — | — | EP | disclosed |