Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19019870 | 0.83 | CHRNB2 (0.43) | LMNATSHRRAB9AGRIN1GRIN2B | |
| SCHEMBL19062035 | 0.81 | HSD17B10 (0.40) | GRIN1GRIN2BCHRNB2CHRNA4HSD17B10 | |
| SCHEMBL19061593 | 0.80 | ALDH1A1 (0.46) | RAB9ACHRNB2CHRNA4HSD17B10PKM | |
| SCHEMBL19061954 | 0.78 | HSD17B10 (0.42) | RAB9AGRIN1GRIN2BCHRNB2CHRNA4 | |
| SCHEMBL19061459 | 0.78 | RAB9A (0.46) | LMNARAB9AGRIN1GRIN2BCHRNB2 | |
| SCHEMBL19019922 | 0.77 | MAPK1 (0.50) | RAB9ACHRNB2CHRNA4HSD17B10PKM | |
| SCHEMBL19062036 | 0.76 | POLB (0.44) | CHRNB2CHRNA4HSD17B10PKMMAPK1 | |
| SCHEMBL19061452 | 0.76 | PKM (0.48) | CHRNB2CHRNA4HSD17B10PKMMAPK1 | |
| SCHEMBL19061884 | 0.76 | KMT2A (0.49) | LMNATSHRRAB9ACHRNB2CHRNA4 | |
| SCHEMBL19061731 | 0.76 | POLB (0.40) | CHRNB2CHRNA4HSD17B10PKMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184514-A1 | AUTOPHAGY INHIBITORS | Deutsches Krebsforschungszentrum (DE) | 2017-06-28 | — | — | EP | disclosed |