Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.63 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | TOP1 | P11387 | 3/20 | 0.62 |
| ▸ | TOP2A | P11388 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | BLM | P54132 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.56 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19175932 | 0.91 | DGAT1 (0.59) | DGAT1SOAT1KCNH2ALDH1A1SMN1; SMN2 | |
| SCHEMBL19137939 | 0.90 | DGAT1 (0.61) | DGAT1SOAT1KCNH2ALDH1A1SMN1; SMN2 | |
| SCHEMBL19137938 | 0.88 | NPBWR1 (0.59) | DGAT1SOAT1KCNH2ALDH1A1SMN1; SMN2 | |
| SCHEMBL19137962 | 0.87 | DGAT1 (0.67) | DGAT1SOAT1KCNH2ALDH1A1SMN1; SMN2 | |
| SCHEMBL19137947 | 0.87 | CCR2 (0.58) | DGAT1SOAT1KCNH2ALDH1A1SMN1; SMN2 | |
| SCHEMBL23709610 | 0.86 | ALDH1A1 (0.61) | DGAT1SOAT1KCNH2ALDH1A1SMN1; SMN2 | |
| SCHEMBL19137934 | 0.86 | ACHE (0.69) | DGAT1SOAT1KCNH2ALDH1A1SMN1; SMN2 | |
| SCHEMBL19137933 | 0.86 | RHEB (0.58) | DGAT1SOAT1KCNH2ALDH1A1SMN1; SMN2 | |
| SCHEMBL21017604 | 0.85 | DGAT1 (0.63) | DGAT1SOAT1KCNH2ALDH1A1SMN1; SMN2 | |
| SCHEMBL24075398 | 0.85 | DGAT1 (0.66) | DGAT1SOAT1KCNH2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339144-B2 | Heteroaryl Rheb inhibitors and uses thereof | NAVITOR PHARMACEUTICALS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-11339144-B2 | Heteroaryl Rheb inhibitors and uses thereof | NAVITOR PHARMACEUTICALS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-20210238165-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. | 2021-08-05 | — | — | US | disclosed |
| US-20210238165-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. | 2021-08-05 | — | — | US | disclosed |
| WO-2018191146-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-10-18 | — | — | WO | disclosed |
| US-20170210741-A1 | Benzimidazole Compounds, Use As Inhibitors of WNT Signaling Pathway in Cancers, and Methods for Preparation Thereof | SOUTHERN RESEARCH INSTITUTE | 2017-07-27 | — | — | US | disclosed |
| US-20170210741-A1 | Benzimidazole Compounds, Use As Inhibitors of WNT Signaling Pathway in Cancers, and Methods for Preparation Thereof | SOUTHERN RESEARCH INSTITUTE | 2017-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210238165-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | RHEB, KRAS, NRAS | DGAT1 3962/4885SOAT1 3072/4885KCNH2 4734/4885 |
| US-20170210741-A1 | Benzimidazole Compounds, Use As Inhibitors of WNT Signaling Pathway in Cancers, and Methods for Preparation Thereof | WNT1, WNT3, CTNNB1 | DGAT1 2252/4885SOAT1 2222/4885KCNH2 4391/4885 |
| US-11339144-B2 | Heteroaryl Rheb inhibitors and uses thereof | RHEB, GDI2, KRAS | DGAT1 2656/4885SOAT1 1694/4885KCNH2 4479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.