Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CDK4 | P11802 | 2/20 | 0.40 |
| ▸ | CCND1 | P24385 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GPR3 | P46089 | 1/20 | 0.39 |
| ▸ | MAP3K9 | P80192 | 2/20 | 0.38 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | PRKCB | P05771 | 1/20 | 0.38 |
| ▸ | GLI1 | P08151 | 1/20 | 0.38 |
| ▸ | GLI2 | P10070 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25757649 | 0.80 | MAPT (0.48) | CA12CA9KDM4EAURKAKDR | |
| SCHEMBL12406712 | 0.75 | KDM4E (0.44) | CA12CA9PDPK1PARP1ALOX15 | |
| SCHEMBL8585832 | 0.73 | GRM2 (0.47) | CA12CA9CDK4CCND1PDPK1 | |
| Phenanthridine SCHEMBL28057333 | 0.73 | CA12 (0.58) | CA12CA9PDPK1PARP1SMN1; SMN2 | |
| SCHEMBL30301327 | 0.72 | KDM4E (0.46) | CA12CA9CDK4CCND1PDPK1 | |
| SCHEMBL16352244 | 0.71 | MAOA (0.52) | SMN1; SMN2KDM4EGPR3 | |
| SCHEMBL31069613 | 0.70 | AURKA (0.47) | CA12CA9CDK4CCND1PARP1 | |
| SCHEMBL14169500 | 0.70 | PDPK1 (0.45) | PDPK1ALOX15SMN1; SMN2KDM4EKDR | |
| SCHEMBL30433945 | 0.69 | CDK4 (0.51) | CA12CA9CDK4CCND1PDPK1 | |
| SCHEMBL5316728 | 0.69 | CDK4 (0.51) | CA12CA9CDK4CCND1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2326645-B9 | COMPOUND WITH SEROTONINERGIC ACTIVITY, PROCESS FOR PREPARING IT AND PHARMACEUTICAL COMPOSITION COMPRISING IT | ACRAF (IT) | 2013-04-17 | — | — | EP | disclosed |
| EP-2326645-B1 | COMPOUND WITH SEROTONINERGIC ACTIVITY, PROCESS FOR PREPARING IT AND PHARMACEUTICAL COMPOSITION COMPRISING IT | ACRAF (IT) | 2012-11-07 | — | — | EP | disclosed |
| US-20110160201-A1 | COMPOUND WITH SEROTONINERGIC ACTIVITY, PROCESS FOR PREPARING IT AND PHARMACEUTICAL COMPOSITION COMPRISING IT | AZIENDE CHIMI. RIUN. ANG. FRANC. A.C.R.A.F. S.p.A. (IT) | 2011-06-30 | — | — | US | disclosed |
| EP-2326645-A1 | COMPOUND WITH SEROTONINERGIC ACTIVITY, PROCESS FOR PREPARING IT AND PHARMACEUTICAL COMPOSITION COMPRISING IT | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A. (IT) | 2011-06-01 | — | — | EP | disclosed |
| WO-2010012611-A1 | COMPOUND WITH SEROTONINERGIC ACTIVITY, PROCESS FOR PREPARING IT AND PHARMACEUTICAL COMPOSITION COMPRISING IT | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2010-02-04 | — | — | WO | disclosed |
| EP-1018512-B1 | Novel basic derivatives of benz(e)isoindol-1-ones and pyrrolo(3,4-c)quinolin-1-ones with 5-HT3-antagonistic activity, their preparation and their therapeutic use | ROTTA RESEARCH LAB (IT) | 2004-06-16 | — | — | EP | disclosed |
| EP-1018512-B1 | Novel basic derivatives of benz(e)isoindol-1-ones and pyrrolo(3,4-c)quinolin-1-ones with 5-HT3-antagonistic activity, their preparation and their therapeutic use | ROTTA RESEARCH LAB (IT) | 2004-06-16 | — | — | EP | disclosed |
| US-6413978-B1 | THERAPY FOR CENTRAL NERVOUS SYSTEM DISORDERS | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 2002-07-02 | — | — | US | disclosed |
| US-6413978-B1 | THERAPY FOR CENTRAL NERVOUS SYSTEM DISORDERS | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 2002-07-02 | — | — | US | disclosed |
| US-6413978-B1 | THERAPY FOR CENTRAL NERVOUS SYSTEM DISORDERS | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 2002-07-02 | — | — | US | disclosed |
| US-20020042426-A1 | Novel basic derivatives of benz[e] isoindol-1-ones and pyrrolo[3,4-c] quinolin-1ones with 5-HT3-antagonistic activity, their preparation and their therapeutic use | ROTTA RESEARCH LABORATORIUM S.P.A. | 2002-04-11 | — | — | US | disclosed |
| US-20020042426-A1 | Novel basic derivatives of benz[e] isoindol-1-ones and pyrrolo[3,4-c] quinolin-1ones with 5-HT3-antagonistic activity, their preparation and their therapeutic use | ROTTA RESEARCH LABORATORIUM S.P.A. | 2002-04-11 | — | — | US | disclosed |
| US-6323216-B1 | SELECTIVE ANTAGONISTS OF THE 5-HT.SUB.3 SEROTONIN-LIKE RECEPTOR AND CAN THEREFORE BE USED, AS ANTI-EMETICS AS WELL AS IN VARIOUS PATHOLOGICAL CONDITIONS OF THE CENTRAL NERVOUS SYSTEM, AND AS ANTITUSSIVES. | ROTTA RESEARCH LABORATORIUM S.P.A (IT) | 2001-11-27 | — | — | US | disclosed |
| US-6323216-B1 | SELECTIVE ANTAGONISTS OF THE 5-HT.SUB.3 SEROTONIN-LIKE RECEPTOR AND CAN THEREFORE BE USED, AS ANTI-EMETICS AS WELL AS IN VARIOUS PATHOLOGICAL CONDITIONS OF THE CENTRAL NERVOUS SYSTEM, AND AS ANTITUSSIVES. | ROTTA RESEARCH LABORATORIUM S.P.A (IT) | 2001-11-27 | — | — | US | disclosed |
| US-6323216-B1 | SELECTIVE ANTAGONISTS OF THE 5-HT.SUB.3 SEROTONIN-LIKE RECEPTOR AND CAN THEREFORE BE USED, AS ANTI-EMETICS AS WELL AS IN VARIOUS PATHOLOGICAL CONDITIONS OF THE CENTRAL NERVOUS SYSTEM, AND AS ANTITUSSIVES. | ROTTA RESEARCH LABORATORIUM S.P.A (IT) | 2001-11-27 | — | — | US | disclosed |
| EP-1018512-A1 | Novel basic derivatives of benz(e)isoindol-1-ones and pyrrolo(3,4-c)quinolin-1-ones with 5-HT3-antagonistic activity, their preparation and their therapeutic use | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 2000-07-12 | — | — | EP | disclosed |
| EP-1018512-A1 | Novel basic derivatives of benz(e)isoindol-1-ones and pyrrolo(3,4-c)quinolin-1-ones with 5-HT3-antagonistic activity, their preparation and their therapeutic use | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 2000-07-12 | — | — | EP | disclosed |
| EP-1018512-A1 | Novel basic derivatives of benz(e)isoindol-1-ones and pyrrolo(3,4-c)quinolin-1-ones with 5-HT3-antagonistic activity, their preparation and their therapeutic use | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 2000-07-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160201-A1 | COMPOUND WITH SEROTONINERGIC ACTIVITY, PROCESS FOR PREPARING IT AND PHARMACEUTICAL COMPOSITION COMPRISING IT | TPH1, TPH2, HTR1A | CA12 4224/4885CA9 3971/4885CDK4 2476/4885 |
| US-20020042426-A1 | Novel basic derivatives of benz[e] isoindol-1-ones and pyrrolo[3,4-c] quinolin-1ones with 5-HT3-antagonistic activity, their preparation and their therapeutic use | HTR3C, HTR3A, TPH1 | CA12 4878/4885CA9 4836/4885CDK4 2548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.