Nifuraldezone

Nifuraldezone

SCHEMBL193103

NC(=O)C(=O)NN=Cc1ccc([N+](=O)[O-])o1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 5/20 0.80
ALDH1A1 P00352 5/20 0.80
CYP3A4 P08684 3/20 0.80
CYP1A2 P05177 3/20 0.80
KDM4E B2RXH2 3/20 0.80
SMN1; SMN2 Q16637 3/20 0.80
TP53 P04637 2/20 0.80
CYP2D6 P10635 1/20 0.80
HIF1A Q16665 1/20 0.80
PDE3A Q14432 1/20 0.80
SARM1 Q6SZW1 1/20 0.80
TDP1 Q9NUW8 4/20 0.71
HTT P42858 2/20 0.71
POLB P06746 7/20 0.67
L3MBTL1 Q9Y468 2/20 0.64
CASP6 P55212 1/20 0.64
MAPT P10636 6/20 0.63
RAB9A P51151 4/20 0.63
MITF O75030 4/20 0.63
MEN1 O00255 2/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nifuraldezone SCHEMBL193102 1.00 LMNA (0.80) LMNAALDH1A1CYP3A4CYP1A2KDM4E
Nitrofurazone SCHEMBL25417 0.89 LMNA (1.00) LMNAALDH1A1CYP3A4CYP1A2KDM4E
Nitrofurazone SCHEMBL25416 0.89 LMNA (1.00) LMNAALDH1A1CYP3A4CYP1A2KDM4E
Nitrofurazone SCHEMBL3681048 0.89 LMNA (1.00) LMNAALDH1A1CYP3A4CYP1A2KDM4E
Nitrofurazone SCHEMBL28198181 0.87 LMNA (0.97) LMNAALDH1A1CYP3A4CYP1A2KDM4E
Nitrofurazone SCHEMBL28285714 0.86 LMNA (0.94) LMNAALDH1A1CYP3A4CYP1A2KDM4E
Furaguanidine SCHEMBL29870771 0.83 LMNA (0.75) LMNAALDH1A1CYP3A4CYP1A2KDM4E
Nihydrazone SCHEMBL525528 0.83 HTT (1.00) LMNAALDH1A1CYP3A4CYP1A2KDM4E
Nihydrazone SCHEMBL525529 0.83 HTT (1.00) LMNAALDH1A1CYP3A4CYP1A2KDM4E
Nitrofurazone SCHEMBL20775188 0.83 LMNA (0.87) LMNAALDH1A1CYP3A4CYP1A2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1136 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220169680-A1 CELL-PENETRATING PEPTIDE BASED ON INFLUENZA VIRUS M2 PROTEIN INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES (CN) 2022-06-02 US claimed
EP-3912989-A1 CELL-PENETRATING PEPTIDE BASED ON INFLUENZA VIRUS M2 PROTEIN Institute of Basic Medical Sciences Chinese Academy of Medical Sciences (CN) 2021-11-24 EP claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20130252945-A1 AMORPHOUS BIOINORGANIC IONIC LIQUID COMPOSITIONS COMPRISING PHARMACEUTICALS LOS ALAMOS NAT SECURITY LLC (US) 2013-09-26 US claimed
US-8268352-B2 Modified release composition for highly soluble drugs TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-18 US claimed
US-8263125-B2 Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-11 US claimed
US-20120093759-A1 Medical Devices, Wound Dressings, and Methods for Dressing Wounds VACHON DAVID J (US) 2012-04-19 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
WO-2009059191-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF EAR CANAL INFECTION AND INFLAMMATION EVERETT LABORATORIES, INC. (US) 2009-05-07 WO claimed
US-20090111780-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF EAR CANAL INFECTION AND INFLAMMATION EVERETT LABORATORIES, INC. 2009-04-30 US claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-20070093462-A1 Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA 2007-04-26 US claimed
WO-2007044693-A2 MULTI-FUNCTIONAL IONIC LIQUID COMPOSITIONS THE UNIVERSITY OF ALABAMA (US) 2007-04-19 WO claimed
US-20060024365-A1 Novel dosage form VAYA NAVIN 2006-02-02 US claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20060018934-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
EP-1578434-A2 METHODS AND COMPOSITIONS RELATING TO ISOLEUCINE BOROPROLINE COMPOUNDS Point Therapeutics, Inc. (US) 2005-09-28 EP claimed
US-20040131628-A1 Nucleic acids for the treatment of disorders associated with microorganisms BRATZLER ROBERT L (US) 2004-07-08 US claimed
US-20040077601-A1 Methods and compositions relating to isoleucine boroproline compounds POINT THERAPEUTICS, INC. 2004-04-22 US claimed
WO-2004004658-A2 METHODS AND COMPOSITIONS RELATING TO ISOLEUCINE BOROPROLINE COMPOUNDS POINT THERAPEUTICS, INC. (US) 2004-01-15 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070093462-A1 Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients SLC5A6, PNLIP, IPMK LMNA 1556/4885ALDH1A1 2937/4885CYP3A4 1130/4885
US-20130252945-A1 AMORPHOUS BIOINORGANIC IONIC LIQUID COMPOSITIONS COMPRISING PHARMACEUTICALS MCOLN1, PYM1, MCOLN2 LMNA 592/4885ALDH1A1 2641/4885CYP3A4 554/4885
US-20040077601-A1 Methods and compositions relating to isoleucine boroproline compounds BCAT1, BCAT2, APOB LMNA 250/4885ALDH1A1 2720/4885CYP3A4 811/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.