SCHEMBL19348271

SCHEMBL19348271

COC(=O)C(=O)N1CCCC1Cc1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FKBP1A P62942 1/20 0.58
GABRA1 P14867 1/20 0.55
GABRG2 P18507 1/20 0.55
GABRB3 P28472 1/20 0.55
GABRA3 P34903 1/20 0.55
GABRA2 P47869 1/20 0.55
GABRB2 P47870 1/20 0.55
HSD11B1 P28845 1/20 0.51
SCD5 Q86SK9 1/20 0.50
ROCK2 O75116 1/20 0.48
TACR1 P25103 1/20 0.47
DAGLA Q9Y4D2 6/20 0.47
HRH3 Q9Y5N1 1/20 0.46
MEN1 O00255 1/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
KMT2A Q03164 1/20 0.46
DAGLB Q8NCG7 4/20 0.46
ABHD6 Q9BV23 4/20 0.46
ATM Q13315 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19367185 1.00 FKBP1A (0.58) FKBP1AGABRA1GABRG2GABRB3GABRA3
SCHEMBL19367184 1.00 FKBP1A (0.58) FKBP1AGABRA1GABRG2GABRB3GABRA3
SCHEMBL28196727 0.86 PSEN1 (0.53) GABRA1GABRG2GABRB3GABRA3GABRA2
SCHEMBL11378515 0.81 ABCB1 (0.57) GABRA1GABRG2GABRB3GABRA3GABRA2
SCHEMBL23459127 0.81 SCD5 (0.57) GABRA1GABRG2GABRB3GABRA3GABRA2
SCHEMBL908981 0.81 SCD5 (0.57) GABRA1GABRG2GABRB3GABRA3GABRA2
SCHEMBL698218 0.80 NR1H2 (0.54) GABRA1GABRG2GABRB3GABRA3GABRA2
SCHEMBL698422 0.80 NR1H2 (0.54) GABRA1GABRG2GABRB3GABRA3GABRA2
SCHEMBL27854990 0.80 NR1H2 (0.54) GABRA1GABRG2GABRB3GABRA3GABRA2
SCHEMBL19367191 0.78 FKBP1A (0.62) FKBP1AGABRA1GABRG2GABRB3GABRA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020191265-A1 METHODS FOR TREATING PULMONARY FIBROSIS DAVID WEINSTEIN CONSULTING, INC. (US) 2020-09-24 WO disclosed
US-10709686-B2 Methods for treating pulmonary fibrosis DAVID WEINSTEIN CONSULTING, INC. (US) 2020-07-14 US disclosed
US-10709686-B2 Methods for treating pulmonary fibrosis DAVID WEINSTEIN CONSULTING, INC. (US) 2020-07-14 US disclosed
US-20190290612-A1 METHODS FOR TREATING PULMONARY FIBROSIS DAVID WEINSTEIN CONSULTING INC (US) 2019-09-26 US disclosed
US-20190290612-A1 METHODS FOR TREATING PULMONARY FIBROSIS DAVID WEINSTEIN CONSULTING INC (US) 2019-09-26 US disclosed
EP-3432987-A1 METHODS FOR WOUND HEALING AND SCAR PREVENTION Weinstein, David (US) 2019-01-30 EP disclosed
US-20180140576-A1 METHODS FOR WOUND HEALING AND SCAR PREVENTION DAVID WEINSTEIN CONSULTING INC (US) 2018-05-24 US disclosed
US-20180140576-A1 METHODS FOR WOUND HEALING AND SCAR PREVENTION DAVID WEINSTEIN CONSULTING INC (US) 2018-05-24 US disclosed
US-20180140576-A1 METHODS FOR WOUND HEALING AND SCAR PREVENTION DAVID WEINSTEIN CONSULTING INC (US) 2018-05-24 US disclosed
WO-2017165119-A1 METHODS FOR WOUND HEALING AND SCAR PREVENTION WEINSTEIN DAVID (US) 2017-09-28 WO disclosed
WO-2017165119-A1 METHODS FOR WOUND HEALING AND SCAR PREVENTION WEINSTEIN DAVID (US) 2017-09-28 WO disclosed
US-20170266157-A1 METHODS FOR WOUND HEALING AND SCAR PREVENTION DAVID WEINSTEIN CONSULTING, INC. 2017-09-21 US disclosed
US-20170266157-A1 METHODS FOR WOUND HEALING AND SCAR PREVENTION DAVID WEINSTEIN CONSULTING, INC. 2017-09-21 US disclosed
US-20170266157-A1 METHODS FOR WOUND HEALING AND SCAR PREVENTION DAVID WEINSTEIN CONSULTING, INC. 2017-09-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10709686-B2 Methods for treating pulmonary fibrosis FKBP4, FKBP1B, FKBP3 FKBP1A 7/4885GABRA1 2619/4885GABRG2 2600/4885
US-20180140576-A1 METHODS FOR WOUND HEALING AND SCAR PREVENTION FKBP4, S100A4, FKBP14 FKBP1A 5/4885GABRA1 3278/4885GABRG2 3211/4885
US-20170266157-A1 METHODS FOR WOUND HEALING AND SCAR PREVENTION FKBP4, S100A4, FKBP14 FKBP1A 5/4885GABRA1 3278/4885GABRG2 3211/4885
US-20190290612-A1 METHODS FOR TREATING PULMONARY FIBROSIS FKBP4, FKBP1B, FKBP3 FKBP1A 7/4885GABRA1 2619/4885GABRG2 2600/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.