Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 3/20 | 0.35 |
| ▸ | BRAF | P15056 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365904 | 0.88 | MAPT (0.43) | CA2CA9MAPTSMN1; SMN2NPC1 | |
| SCHEMBL16776293 | 0.85 | CA2 (0.38) | CA2CA9SMN1; SMN2RAF1BRAF | |
| SCHEMBL17618766 | 0.85 | MEN1 (0.39) | CA2CA9MAPTSMN1; SMN2RAF1 | |
| SCHEMBL19365708 | 0.84 | MAPT (0.41) | CA2CA9MAPTSMN1; SMN2NPC1 | |
| SCHEMBL19365254 | 0.82 | HTR2C (0.47) | MAPTSMN1; SMN2NPC1KMT2AMEN1 | |
| SCHEMBL19670411 | 0.82 | MAPT (0.41) | CA2CA9MAPTSMN1; SMN2NPC1 | |
| SCHEMBL19365568 | 0.82 | RHOA (0.50) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL19365595 | 0.82 | MAPT (0.38) | CA2CA9MAPTSMN1; SMN2NPC1 | |
| SCHEMBL19865057 | 0.82 | RHOA (0.41) | CA2CA9MAPTSMN1; SMN2NPC1 | |
| SCHEMBL19365468 | 0.82 | CA2 (0.39) | CA2CA9MAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |