Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.33 |
| ▸ | NEK2 | P51955 | 1/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 3/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670584 | 0.89 | FAAH (0.41) | POLQHCRTR2CNR1GSK3BDYRK1A | |
| SCHEMBL19365269 | 0.88 | KARS1 (0.45) | GSK3BDYRK1AIRAK4KARS1TRPV3 | |
| SCHEMBL19365517 | 0.87 | BRAF (0.40) | GSK3BDYRK1ABRAF | |
| SCHEMBL19365522 | 0.86 | KDM4E (0.39) | DYRK1AIRAK4NEK2BRAFEGFR | |
| SCHEMBL17618601 | 0.85 | POLQ (0.38) | POLQHCRTR2CNR1GSK3BDYRK1A | |
| SCHEMBL19670515 | 0.85 | WNT3A (0.35) | GSK3BABL1 | |
| SCHEMBL19365745 | 0.85 | DHFR (0.38) | GSK3BDYRK1AIRAK4KARS1TRPV3 | |
| SCHEMBL19670153 | 0.84 | VCP (0.41) | GSK3BDYRK1AKARS1TRPV3HTR1A | |
| SCHEMBL19670365 | 0.84 | VCP (0.37) | HCRTR2CNR1GSK3BDYRK1ATRPV3 | |
| SCHEMBL19364877 | 0.84 | TRPV3 (0.38) | CNR1GSK3BDYRK1ATRPV3ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |