Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.37 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.37 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.37 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.37 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.39 |
| ▸ | TACR2 | P21452 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1936605 | 0.93 | HTR4 (0.44) | HTR4CCR2NPC1OPRK1UTS2R | |
| Fumaric Acid SCHEMBL1934781 | 0.89 | CCR2 (0.39) | CCR2OPRK1UTS2RSLC6A2SLC6A4 | |
| Fumaric Acid SCHEMBL1936426 | 0.88 | HTR4 (0.39) | HTR4CCR2NPC1OPRK1UTS2R | |
| Fumaric Acid SCHEMBL1937621 | 0.86 | SLC6A4 (0.43) | HTR4SLC6A2SLC6A4SLC6A3 | |
| Fumaric Acid SCHEMBL1936521 | 0.86 | ACHE (0.41) | HTR4CCR2UTS2RTACR2HRH1 | |
| SCHEMBL2397352 | 0.82 | OPRK1 (0.42) | CCR2OPRK1UTS2RMEN1KMT2A | |
| Fumaric Acid SCHEMBL2548804 | 0.82 | CCR5 (0.38) | HTR4TACR2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1937237 | 0.80 | HTR4 (0.43) | HTR4OPRK1UTS2RTACR2SLC6A2 | |
| Fumaric Acid SCHEMBL1937182 | 0.79 | HTR4 (0.37) | HTR4NPC1LMNAMAPK1DRD2 | |
| Fumaric Acid SCHEMBL27834013 | 0.79 | HTR4 (0.37) | HTR4NPC1LMNAMAPK1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110218217-A1 | PIPERIDYLPROPIONAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS INCLUDING DEPRESSION AND PANIC DISORDER | NEUROSEARCH A/S (DK) | 2011-09-08 | — | — | US | disclosed |
| EP-2331504-A2 | PIPERIDYLPROPIONAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS INCLUDING DEPRESSION AND PANIC DISORDER | NeuroSearch A/S (DK) | 2011-06-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218217-A1 | PIPERIDYLPROPIONAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS INCLUDING DEPRESSION AND PANIC DISORDER | SLC18A2, SLC1A2, PNMT | MEN1 2706/4885KMT2A 1046/4885SLC6A2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.