Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL194002 | 0.92 | LMNA (0.62) | MEN1LMNAKMT2AFFAR3LCK | |
| Tromethamine SCHEMBL4581519 | 0.92 | LMNA (0.62) | MEN1LMNAKMT2AFFAR3LCK | |
| Tromethamine SCHEMBL7347818 | 0.92 | LMNA (0.62) | MEN1LMNAKMT2AFFAR3LCK | |
| Tromethamine SCHEMBL3473649 | 0.84 | LMNA (0.53) | MEN1LMNAKMT2AFFAR3LCK | |
| Tromethamine SCHEMBL5710709 | 0.83 | LMNA (0.67) | MEN1LMNAKMT2AS1PR1 | |
| Tromethamine SCHEMBL4950340 | 0.83 | MEN1 (0.77) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL29111702 | 0.82 | LMNA (0.50) | MEN1LMNAKMT2AFFAR3LCK | |
| Tromethamine SCHEMBL19183294 | 0.80 | LMNA (0.62) | MEN1LMNAKMT2AS1PR1 | |
| Tromethamine SCHEMBL2898170 | 0.80 | MEN1 (0.48) | MEN1LMNAKMT2AFFAR3LCK | |
| Tromethamine SCHEMBL8668436 | 0.80 | LMNA (0.71) | MEN1LMNAKMT2AS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120322064-A1 | HYBRIDIZATION PROBES AND METHODS OF THEIR USE | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2012-12-20 | — | — | US | disclosed |
| US-7029881-B1 | Methods for constructing DNA library and support carrying DNA library immobilized thereon | NIHON PARKERIZING HIROSHIMA CO., LTD. (JP) | 2006-04-18 | — | — | US | disclosed |