Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | GABRR1 | P24046 | 3/20 | 0.32 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.32 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.32 |
| ▸ | ODC1 | P11926 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL29111702 | 0.97 | LMNA (0.50) | LMNAKMT2AMEN1FFAR3LCK | |
| Tromethamine SCHEMBL7347818 | 0.92 | LMNA (0.62) | LMNAKMT2AMEN1FFAR3LCK | |
| Tromethamine SCHEMBL194002 | 0.92 | LMNA (0.62) | LMNAKMT2AMEN1FFAR3LCK | |
| Tromethamine SCHEMBL4581519 | 0.92 | LMNA (0.62) | LMNAKMT2AMEN1FFAR3LCK | |
| Tromethamine SCHEMBL5891164 | 0.84 | MEN1 (0.53) | LMNAKMT2AMEN1FFAR3LCK | |
| Acetic Acid SCHEMBL9509800 | 0.84 | MEN1 (0.45) | LMNAKMT2AMEN1FFAR3LCK | |
| Tromethamine SCHEMBL5710709 | 0.83 | LMNA (0.67) | LMNAKMT2AMEN1S1PR1BLM | |
| Tromethamine SCHEMBL3761763 | 0.83 | MEN1 (0.77) | LMNAKMT2AMEN1KDM4ETSHR | |
| Acetic Acid SCHEMBL27666617 | 0.83 | FFAR3 (0.54) | LMNAKMT2AMEN1FFAR3LCK | |
| Acetic Acid SCHEMBL5150444 | 0.80 | FFAR3 (0.44) | LMNAKMT2AMEN1FFAR3LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116926971-B | Antigen fibrillation composition and application thereof in lyocell fabric | 广东德美精细化工集团股份有限公司 | 2024-07-12 | — | — | CN | claimed |
| CN-117090052-A | Preparation method of antigen fibrillated lyocell fibers | 广东德美精细化工集团股份有限公司 | 2023-11-21 | — | — | CN | claimed |
| CN-116926971-A | Antigen fibrillation composition and application thereof in lyocell fabric | 广东德美精细化工集团股份有限公司 | 2023-10-24 | — | — | CN | claimed |
| CN-116323968-A | Decrosslinking compounds for spatial analysis and methods of use | 10X基因组学有限公司 | 2023-06-23 | — | — | CN | claimed |
| CN-110964636-A | Automatic nucleic acid magnetic bead purification micro-fluidic chip based on laminar flow | 东南大学 | 2020-04-07 | — | — | CN | claimed |
| CN-116926971-B | Antigen fibrillation composition and application thereof in lyocell fabric | 广东德美精细化工集团股份有限公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-118146257-A | Phosphatidylamide compound containing multiple tertiary amino structures, composition and application thereof | 北京大学 | 2024-06-07 | — | — | CN | disclosed |
| CN-118146262-A | Bi-phosphatidyl amide compound containing multiple tertiary amino structures, composition and application thereof | 北京大学 | 2024-06-07 | — | — | CN | disclosed |
| CN-112439079-B | Preparation of medicine-carrying cage-shaped protein by organic solvent method | 昆山新蕴达生物科技有限公司 | 2024-04-12 | — | — | CN | disclosed |
| CN-117090052-A | Preparation method of antigen fibrillated lyocell fibers | 广东德美精细化工集团股份有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-116926971-A | Antigen fibrillation composition and application thereof in lyocell fabric | 广东德美精细化工集团股份有限公司 | 2023-10-24 | — | — | CN | disclosed |
| CN-116323968-A | Decrosslinking compounds for spatial analysis and methods of use | 10X基因组学有限公司 | 2023-06-23 | — | — | CN | disclosed |
| WO-2009035739-A2 | UNIVERSAL MATRIX | NORTHWESTERN UNIVERSITY (US) | 2009-03-19 | — | — | WO | disclosed |
| EP-0669986-B1 | FULLY IMPAIRED CONSENSUS KOZAC SEQUENCES FOR MAMMALIAN EXPRESSION | IDEC PHARMA CORP (US) | 2003-04-09 | — | — | EP | disclosed |
| US-20030036113-A1 | Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same | BIOGEN IDEC INC. | 2003-02-20 | — | — | US | disclosed |
| US-6159730-A | Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same | IDEC PHARMACEUTICAL CORPORATION (US) | 2000-12-12 | — | — | US | disclosed |
| US-6017733-A | TRANFORMING MAMMALIAN CELLS WITH AN EXPRESSION VECTOR THAT CONTAINS A FULLY IMPAIRED CONSENSUS KOZAK SEQUENCE AND A GENE ENCODED A TARGET DNA WITHIN THE INSERTION REGION; INCREASE EXPRESSION EFFICIENCY OF THE GENE PRODUCT OF INTEREST | IDEC PHARMACEUTICALS CORPORATION (US) | 2000-01-25 | — | — | US | disclosed |
| WO-1998016540-A1 | IMPROVED COUPLING ACTIVATORS FOR OLIGONUCLEOTIDE SYNTHESIS | PROLIGO LLC (US) | 1998-04-23 | — | — | WO | disclosed |
| US-5733779-A | GENETIC ENGINEERING | IDEC PHARMACEUTICALS CORPORATION (US) | 1998-03-31 | — | — | US | disclosed |
| US-5648267-A | Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same | IDEC PHARMACEUTICALS CORPORATION (US) | 1997-07-15 | — | — | US | disclosed |