Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.38 |
| ▸ | PARP11 | Q9NR21 | 3/20 | 0.38 |
| ▸ | PARP1 | P09874 | 4/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.33 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.33 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.33 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29521546 | 1.00 | PARP10 (0.38) | PARP10PARP11PARP1S1PR1AR | |
| SCHEMBL17491410 | 0.80 | S1PR1 (0.37) | PARP10PARP11PARP1S1PR1AR | |
| SCHEMBL23384792 | 0.77 | UHRF1 (0.34) | PARP10PARP11PARP1UHRF1NOTUM | |
| SCHEMBL1761215 | 0.76 | UGT2B17 (0.36) | PARP10PARP11PARP1RAPGEF4UHRF1 | |
| SCHEMBL19422711 | 0.76 | HSPA9 (0.33) | HTR2AHTR2CHTR2B | |
| SCHEMBL20939380 | 0.75 | NOTUM (0.42) | PARP10PARP11PARP1UHRF1NOTUM | |
| SCHEMBL12968862 | 0.71 | ASIC3 (0.43) | ADRB1HTR2AHTR2CHTR2B | |
| SCHEMBL24457967 | 0.70 | PARP10 (0.42) | PARP10PARP11PARP1S1PR1AR | |
| SCHEMBL21903872 | 0.70 | KDM1A (0.33) | PARP10PARP11PARP1UHRF1NOTUM | |
| SCHEMBL10118878 | 0.70 | ADRA2A (0.41) | PARP10PARP11PARP1UHRF1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11702387-B2 | Substituted indoline derivatives as dengue viral replication inhibitors | Janssen Pharmaceuticals, Inc. (US) | 2023-07-18 | — | — | US | disclosed |
| CN-110753682-B | Substituted indoline derivatives as dengue virus replication inhibitors | 杨森制药公司 | 2023-06-30 | — | — | CN | disclosed |
| EP-3436436-B1 | SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | JANSSEN PHARMACEUTICALS INC (US) | 2022-05-11 | — | — | EP | disclosed |
| EP-3436436-B1 | SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | JANSSEN PHARMACEUTICALS INC (US) | 2022-05-11 | — | — | EP | disclosed |
| CN-109195949-B | Substituted indoline derivatives as inhibitors of dengue virus replication | 杨森制药公司 | 2021-09-17 | — | — | CN | disclosed |
| EP-3630724-B1 | SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | JANSSEN PHARMACEUTICALS INC (US) | 2021-04-28 | — | — | EP | disclosed |
| US-10913716-B2 | Substituted indoline derivatives as dengue viral replication inhibitors | Janssen Pharmaceuticals, Inc. (US) | 2021-02-09 | — | — | US | disclosed |
| US-20200339511-A1 | Substituted indoline derivatives as dengue viral replication inhibitors | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2020-10-29 | — | — | US | disclosed |
| CN-110753682-A | Substituted indoline derivatives as inhibitors of dengue virus replication | 杨森制药公司 | 2020-02-04 | — | — | CN | disclosed |
| EP-3436436-A1 | SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | Janssen Pharmaceuticals, Inc. (US) | 2019-02-06 | — | — | EP | disclosed |
| CN-109195949-A | The indoline derivative object being substituted as dengue fever virus replication inhibitors | 杨森制药公司 | 2019-01-11 | — | — | CN | disclosed |
| WO-2017167953-A1 | SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | Janssen Pharmaceuticals, Inc. (US) | 2017-10-05 | — | — | WO | disclosed |
| WO-2017167953-A1 | SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | Janssen Pharmaceuticals, Inc. (US) | 2017-10-05 | — | — | WO | disclosed |
| US-20150322068-A1 | SUBSTITUTED XANTHINE DERIVATIVES | SUN PHARMACEUTICAL INDUSTRIES, INC. | 2015-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150322068-A1 | SUBSTITUTED XANTHINE DERIVATIVES | XDH, HPRT1, CXCR3 | PARP10 1503/4885PARP11 1990/4885PARP1 1886/4885 |
| US-10913716-B2 | Substituted indoline derivatives as dengue viral replication inhibitors | IDO1, INMT, IDO2 | PARP10 573/4885PARP11 395/4885PARP1 275/4885 |
| US-11702387-B2 | Substituted indoline derivatives as dengue viral replication inhibitors | IDO1, INMT, IRF3 | PARP10 576/4885PARP11 400/4885PARP1 278/4885 |
| US-20200339511-A1 | Substituted indoline derivatives as dengue viral replication inhibitors | INMT, IDO1, IDO2 | PARP10 498/4885PARP11 472/4885PARP1 251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.