SCHEMBL19456

SCHEMBL19456

O=C1COCCN1c1ccc(Br)cc1

nearest known ligand 0.64

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 11/20 0.64
F10 P00742 5/20 0.54
AKR1C3 P42330 1/20 0.45
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL76558 0.84 F10 (0.58) PTGS2F10
SCHEMBL28834548 0.82 F10 (0.54) PTGS2F10AKR1C3
SCHEMBL28956907 0.82 PTGS2 (0.67) PTGS2F10
SCHEMBL19086541 0.82 PTGS2 (0.64) PTGS2F10
SCHEMBL15628319 0.82 F10 (0.54) PTGS2F10AKR1C3
SCHEMBL18630668 0.82 F10 (0.54) PTGS2F10AKR1C3
SCHEMBL2540317 0.82 F10 (0.54) PTGS2F10
SCHEMBL92872 0.82 PTGS2 (0.64) PTGS2F10AKR1C3
SCHEMBL15846877 0.82 F10 (0.54) PTGS2F10
SCHEMBL198132 0.81 PTGS2 (0.57) PTGS2F10MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118530233-A Preparation method of rivaroxaban and intermediate thereof 武汉工程大学 2024-08-23 CN claimed
US-20260092054-A1 FUSED RING COMPOUND AND PHARMACEUTICAL CONTAINING SAME KAKEN PHARMA CO LTD (JP) 2026-04-02 US disclosed
US-12479816-B2 20-HETE formation inhibitors University of Pittsburgh—of the Commonwealth System of Higher Education (US) 2025-11-25 US disclosed
EP-4596539-A1 FUSED RING COMPOUND AND PHARMACEUTICAL CONTAINING SAME Kaken Pharmaceutical Co., Ltd. (JP) 2025-08-06 EP disclosed
CN-118530233-A Preparation method of rivaroxaban and intermediate thereof 武汉工程大学 2024-08-23 CN disclosed
CN-118530233-A Preparation method of rivaroxaban and intermediate thereof 武汉工程大学 2024-08-23 CN disclosed
WO-2024151547-A1 TARGETED DEGRADATION OF VAV1 MONTE ROSA THERAPEUTICS, INC. (US) 2024-07-18 WO disclosed
WO-2024071439-A1 FUSED RING COMPOUND AND PHARMACEUTICAL CONTAINING SAME 科研製薬株式会社 2024-04-04 WO disclosed
US-20220144797-A1 20-HETE FORMATION INHIBITORS UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2022-05-12 US disclosed
EP-3342765-B1 CATHEPSIN K INHIBITOR AND APPLICATION THEREOF SUNSHINE LAKE PHARMA CO LTD (CN) 2021-09-15 EP disclosed
US-20110263591-A1 2-HETEROARYL CARBOXAMIDES BAYER SCHERING PHARMA AG (DE) 2011-10-27 US disclosed
US-20110263591-A1 2-HETEROARYL CARBOXAMIDES BAYER SCHERING PHARMA AG (DE) 2011-10-27 US disclosed
US-7977485-B2 2-heteroaryl carboxamides BAYER SCHERING PHARMA AKTIENGESELLSHAFT (DE) 2011-07-12 US disclosed
US-7977485-B2 2-heteroaryl carboxamides BAYER SCHERING PHARMA AKTIENGESELLSHAFT (DE) 2011-07-12 US disclosed
US-7977485-B2 2-heteroaryl carboxamides BAYER SCHERING PHARMA AKTIENGESELLSHAFT (DE) 2011-07-12 US disclosed
EP-1515967-B1 2-HETEROARYL CARBOXAMIDES BAYER HEALTHCARE AG (DE) 2006-11-02 EP disclosed
US-20060160877-A1 2-Heteroaryl carboxamides BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2006-07-20 US disclosed
CN-1675204-A 2-heteroaryl carboxamides BAYER HEALTHCARE AG (DE) 2005-09-28 CN disclosed
EP-1515967-A1 2-HETEROARYL CARBOXAMIDES Bayer HealthCare AG (DE) 2005-03-23 EP disclosed
WO-2003104227-A1 2-HETEROARYL CARBOXAMIDES BAYER HEALTHCARE AG (DE) 2003-12-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260092054-A1 FUSED RING COMPOUND AND PHARMACEUTICAL CONTAINING SAME STAT6, HRH4, CCR6 PTGS2 1010/4885F10 3331/4885AKR1C3 234/4885
US-20060160877-A1 2-Heteroaryl carboxamides GRIN2A, CNR2, GRIN2C PTGS2 832/4885F10 4731/4885AKR1C3 4092/4885
US-20220144797-A1 20-HETE FORMATION INHIBITORS CYP4A22, ALOX5, ALOX15 PTGS2 21/4885F10 1662/4885AKR1C3 682/4885
US-12479816-B2 20-HETE formation inhibitors CYP4A22, ALOX5, ALOX15 PTGS2 21/4885F10 1662/4885AKR1C3 682/4885
US-20110263591-A1 2-HETEROARYL CARBOXAMIDES GRIN2A, CNR2, GRIN2C PTGS2 832/4885F10 4731/4885AKR1C3 4092/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.