Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | PDE8B | O95263 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19464063 | 0.88 | RXRA (0.46) | RXRARXRBRXRGPDE8BCYP4F2 | |
| SCHEMBL29705837 | 0.88 | RXRA (0.46) | RXRARXRBRXRGPDE8BCYP4F2 | |
| SCHEMBL19463519 | 0.79 | SLC6A3 (0.39) | RXRARXRBRXRGCYP4F2CYP4A11 | |
| SCHEMBL20874194 | 0.77 | SLC6A3 (0.37) | RXRARXRBRXRGCYP4F2CYP4A11 | |
| SCHEMBL29705852 | 0.76 | LMNA (0.39) | RXRARXRBRXRGCYP4F2CYP4A11 | |
| SCHEMBL19464241 | 0.76 | LMNA (0.39) | RXRARXRBRXRGCYP4F2CYP4A11 | |
| SCHEMBL19463518 | 0.76 | ALDH1A1 (0.48) | RXRARXRBRXRGCYP4F2CYP4A11 | |
| SCHEMBL19463295 | 0.76 | NR3C1 (0.46) | NR3C1ALDH1A1LMNAPDE4B | |
| SCHEMBL19915968 | 0.76 | RXRA (0.45) | RXRARXRBRXRGPDE8BCYP4F2 | |
| SCHEMBL31211036 | 0.75 | CYP4F2 (0.38) | RXRARXRBRXRGCYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10370355-B2 | Tetrahydroisoquinoline derivatives | UCB BIOPHARMA SPRL (BE) | 2019-08-06 | — | — | US | disclosed |
| US-20190106406-A1 | Tetrahydroisoquinoline Derivatives | UCB BIOPHARMA SPRL (BE) | 2019-04-11 | — | — | US | disclosed |
| WO-2017178377-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2017-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190106406-A1 | Tetrahydroisoquinoline Derivatives | GPR52, GRK3, GPR3 | RXRA 932/4885RXRB 819/4885RXRG 522/4885 |
| US-10370355-B2 | Tetrahydroisoquinoline derivatives | GPR52, GRK3, GPR3 | RXRA 932/4885RXRB 819/4885RXRG 522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.