Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 6/20 | 0.39 |
| ▸ | RGS4 | P49798 | 2/20 | 0.38 |
| ▸ | RGS8 | P57771 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RGS16 | O15492 | 1/20 | 0.37 |
| ▸ | RGS19 | P49795 | 1/20 | 0.37 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18835230 | 0.91 | ALDH1A1 (0.41) | P2RX7RGS4RGS8KMT2AMEN1 | |
| SCHEMBL20432069 | 0.84 | TRPC5 (0.36) | P2RX7KMT2AALDH1A1P2RX3TSHR | |
| SCHEMBL19375051 | 0.84 | MDM2 (0.38) | P2RX7RGS4RGS8P2RX3 | |
| SCHEMBL19375039 | 0.84 | RAB9A (0.36) | P2RX7RGS4RGS8KMT2AMEN1 | |
| SCHEMBL20432432 | 0.83 | PDE5A (0.37) | RGS4RGS8ALDH1A1P2RX3TSHR | |
| SCHEMBL21316348 | 0.83 | ALDH1A1 (0.40) | P2RX7KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL18834436 | 0.82 | PPARG (0.36) | P2RX7KMT2AALDH1A1P2RX3TSHR | |
| SCHEMBL22105398 | 0.81 | MEN1 (0.50) | KMT2AMEN1ALDH1A1HTTNPSR1 | |
| SCHEMBL21316344 | 0.81 | P2RX3 (0.40) | P2RX7KMT2AMEN1ALDH1A1P2RX3 | |
| SCHEMBL21499680 | 0.79 | P2RX3 (0.39) | KMT2AMEN1ALDH1A1P2RX3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969736-B2 | Substituted xanthines and methods of use thereof | HYDRA BIOSCIENCES, INC. (US) | 2018-05-15 | — | — | US | disclosed |
| US-20170305910-A1 | Substituted Xanthines and Methods of Use Thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170305910-A1 | Substituted Xanthines and Methods of Use Thereof | TRPC5, TRPC7, TRPC4 | P2RX7 39/4885RGS4 1425/4885RGS8 1365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.