Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 4/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | AGXT | P21549 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30444190 | 1.00 | CYP2A6 (0.43) | CYP2A6ADRB2ASIC3LOXL2BCL2L1 | |
| SCHEMBL17010954 | 0.84 | ESR1 (0.43) | ESR1ESR2LMNA | |
| SCHEMBL28514083 | 0.81 | BCL2L1 (0.44) | CYP2A6ADRB2ASIC3LOXL2BCL2L1 | |
| SCHEMBL31141892 | 0.81 | BCL2L1 (0.44) | CYP2A6ADRB2ASIC3LOXL2BCL2L1 | |
| SCHEMBL6596113 | 0.80 | CYP2A6 (0.48) | CYP2A6ADRB2ASIC3LOXL2BCL2L1 | |
| SCHEMBL17856939 | 0.72 | CYP2A6 (0.44) | CYP2A6ADRB2ASIC3LOXL2BCL2L1 | |
| SCHEMBL30444116 | 0.72 | CYP2A6 (0.44) | CYP2A6ADRB2ASIC3LOXL2BCL2L1 | |
| SCHEMBL18271669 | 0.69 | MGLL (0.42) | CYP2A6ADRB2ASIC3LOXL2BCL2L1 | |
| SCHEMBL63526 | 0.67 | ESR1 (0.70) | CA4ESR1ESR2LMNAALOX12 | |
| SCHEMBL12921500 | 0.67 | L3MBTL1 (0.44) | ASIC3GAAALOX15CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753421-B2 | Silylated derivatives of aromatic heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2023-09-12 | — | — | US | disclosed |
| US-11753421-B2 | Silylated derivatives of aromatic heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2023-09-12 | — | — | US | disclosed |
| EP-3705482-B1 | SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS | CALIFORNIA INST OF TECHN (US) | 2023-02-22 | — | — | EP | disclosed |
| US-20220185828-A1 | Silylated Derivatives Of Aromatic Heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2022-06-16 | — | — | US | disclosed |
| US-20220162236-A1 | SILYLATIONS OF AROMATIC SUBSTRATES WITH BASE-ACTIVATED ORGANOSILANES | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2022-05-26 | — | — | US | disclosed |
| US-11312733-B2 | Silylated derivatives of aromatic heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2022-04-26 | — | — | US | disclosed |
| US-11230520-B2 | Silylations of aromatic substrates with base-activated organosilanes | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2022-01-25 | — | — | US | disclosed |
| US-20210122701-A1 | SILYLATIONS OF AROMATIC SUBSTRATES WITH BASE-ACTIVATED ORGANOSILANES | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2021-04-29 | — | — | US | disclosed |
| US-10927065-B2 | Silylations of aromatic substrates with base-activated organosilanes | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2021-02-23 | — | — | US | disclosed |
| US-20180155271-A1 | SILYLATIONS OF AROMATIC SUBSTRATES WITH BASE-ACTIVATED ORGANOSILANES | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2018-06-07 | — | — | US | disclosed |
| US-20180155271-A1 | SILYLATIONS OF AROMATIC SUBSTRATES WITH BASE-ACTIVATED ORGANOSILANES | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2018-06-07 | — | — | US | disclosed |
| US-9908840-B2 | Reactions of aromatic substrates with base-activated hydrosilanes-silylations and reductive cleavage | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-03-06 | — | — | US | disclosed |
| US-9908840-B2 | Reactions of aromatic substrates with base-activated hydrosilanes-silylations and reductive cleavage | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-03-06 | — | — | US | disclosed |
| US-20180057514-A1 | SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2018-03-01 | — | — | US | disclosed |
| US-9809607-B2 | Silylation of aromatic heterocycles by earth abundant transition-metal-free catalysts | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10927065-B2 | Silylations of aromatic substrates with base-activated organosilanes | TYR, DDC, TPST2 | CYP2A6 684/4885ADRB2 3192/4885ASIC3 2608/4885 |
| US-20180155271-A1 | SILYLATIONS OF AROMATIC SUBSTRATES WITH BASE-ACTIVATED ORGANOSILANES | TYR, DDC, TPST2 | CYP2A6 684/4885ADRB2 3192/4885ASIC3 2608/4885 |
| US-11230520-B2 | Silylations of aromatic substrates with base-activated organosilanes | TYR, DDC, TPST2 | CYP2A6 684/4885ADRB2 3192/4885ASIC3 2608/4885 |
| US-11312733-B2 | Silylated derivatives of aromatic heterocycles | KCNH1, KCNH3, HNRNPH3 | CYP2A6 2952/4885ADRB2 1447/4885ASIC3 895/4885 |
| US-20220162236-A1 | SILYLATIONS OF AROMATIC SUBSTRATES WITH BASE-ACTIVATED ORGANOSILANES | TYR, DDC, TPST2 | CYP2A6 684/4885ADRB2 3192/4885ASIC3 2608/4885 |
| US-20180057514-A1 | SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS | TEC, AURKA, TYR | CYP2A6 1097/4885ADRB2 2998/4885ASIC3 1561/4885 |
| US-11753421-B2 | Silylated derivatives of aromatic heterocycles | KCNH1, KCNH3, HNRNPH3 | CYP2A6 2952/4885ADRB2 1447/4885ASIC3 895/4885 |
| US-20220185828-A1 | Silylated Derivatives Of Aromatic Heterocycles | KCNH1, KCNH3, HNRNPH3 | CYP2A6 2952/4885ADRB2 1447/4885ASIC3 895/4885 |
| US-20210122701-A1 | SILYLATIONS OF AROMATIC SUBSTRATES WITH BASE-ACTIVATED ORGANOSILANES | TYR, DDC, TPST2 | CYP2A6 684/4885ADRB2 3192/4885ASIC3 2608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.