Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Methaqualone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPD | P32754 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methaqualone SCHEMBL29386732 | 0.85 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1LMNATSHRNPSR1 | |
| Methaqualone SCHEMBL43892 | 0.85 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1LMNATSHRNPSR1 | |
| Methaqualone SCHEMBL29355239 | 0.85 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1LMNATSHRNPSR1 | |
| Methaqualone SCHEMBL20471677 | 0.85 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1LMNATSHRNPSR1 | |
| Methaqualone SCHEMBL29849847 | 0.84 | ALDH1A1 (0.97) | ALDH1A1L3MBTL1LMNATSHRNPSR1 | |
| Methaqualone SCHEMBL3500629 | 0.84 | ALDH1A1 (0.97) | ALDH1A1L3MBTL1LMNATSHRNPSR1 | |
| Methaqualone SCHEMBL29064194 | 0.82 | ALDH1A1 (0.94) | ALDH1A1L3MBTL1LMNATSHRNPSR1 | |
| SCHEMBL11445400 | 0.74 | ALDH1A1 (0.78) | ALDH1A1L3MBTL1LMNATSHRMAPK1 | |
| SCHEMBL16596956 | 0.73 | L3MBTL1 (0.77) | ALDH1A1L3MBTL1LMNATSHRMAPK1 | |
| SCHEMBL9340028 | 0.73 | ALDH1A1 (0.70) | ALDH1A1L3MBTL1LMNATSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021146426-A2 | AEROSOL JET PRINTED FLEXIBLE GRAPHENE CIRCUITS FOR ELECTROCHEMICAL SENSING AND BIOSENSING | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2021-07-22 | — | — | WO | disclosed |
| US-20210215636-A1 | AEROSOL JET PRINTED FLEXIBLE GRAPHENE CIRCUITS FOR ELECTROCHEMICAL SENSING AND BIOSENSING | NATIONAL SCIENCE FOUNDATION | 2021-07-15 | — | — | US | disclosed |
| US-9979548-B2 | Energy harvesting cryptosystem | CLUTCH AUTHENTICATION SYSTEMS, LLC (US) | 2018-05-22 | — | — | US | disclosed |
| US-20170337369-A1 | ENERGY HARVESTING CRYPTOSYSTEM | CLUTCH AUTHENTICATION SYSTEMS, LLC (US) | 2017-11-23 | — | — | US | disclosed |
| US-20170338960-A1 | ENERGY HARVESTING CRYPTOSYSTEM | CLUTCH AUTHENTICATION SYSTEMS, LLC (US) | 2017-11-23 | — | — | US | disclosed |