Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 2/20 | 0.56 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.52 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.52 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.52 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.50 |
| ▸ | HTR3B | O95264 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19612688 | 0.98 | NAAA (0.56) | NAAAPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL8301337 | 0.93 | PLAAT3 (0.58) | NAAAPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL8170713 | 0.88 | NAAA (0.58) | NAAAPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL18126611 | 0.87 | MAPT (0.66) | NAAAPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL3252805 | 0.86 | PLAAT3 (0.55) | PLAAT3PLAAT5PLAAT2PLAAT4SMN1; SMN2 | |
| SCHEMBL11037045 | 0.85 | PLAAT3 (0.58) | NAAAPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL7829175 | 0.85 | SMN1; SMN2 (0.67) | NAAAPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL31567921 | 0.84 | TAAR1 (0.65) | NAAAPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL19612566 | 0.82 | NAAA (0.55) | NAAAFAAHTAAR1HDAC6MAPT | |
| SCHEMBL28877124 | 0.82 | HDAC6 (0.47) | NAAAFAAHHDAC6MAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10174015-B2 | Substituted heterocyclic derivative, preparation method and use thereof | XIAMEN UNIVERSITY (CN) | 2019-01-08 | — | — | US | disclosed |
| US-20170334896-A1 | Substituted Heterocyclic Derivative, Preparation Method And Use Thereof | XIAMEN UNIVERSITY (CN) | 2017-11-23 | — | — | US | disclosed |
| CN-107074788-A | Substituted heterocyclic derivatives, preparation method and application thereof | 厦门大学 | 2017-08-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334896-A1 | Substituted Heterocyclic Derivative, Preparation Method And Use Thereof | FAAH, NAAA, FAAH2 | NAAA 2/4885PLAAT3 305/4885PLAAT5 238/4885 |
| US-10174015-B2 | Substituted heterocyclic derivative, preparation method and use thereof | DHPS, CYP3A5, CYP3A4 | NAAA 557/4885PLAAT3 3681/4885PLAAT5 2714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.