Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 2/20 | 0.32 |
| ▸ | FLT3 | P36888 | 2/20 | 0.32 |
| ▸ | TEK | Q02763 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670172 | 0.86 | ADORA2A (0.37) | CHRM3GCKMTOR | |
| SCHEMBL19669985 | 0.86 | KARS1 (0.43) | TRPV3IRAK4FLT3TEKJAK2 | |
| SCHEMBL19670263 | 0.86 | DHFR (0.37) | TRPV3CDK5CDK5R1NPC1RAB9A | |
| SCHEMBL19670389 | 0.84 | ROCK2 (0.35) | TRPV3MTORJAK2CARM1PRMT6 | |
| SCHEMBL19670393 | 0.83 | ABL1 (0.42) | TRPV3TEKJAK2ABL1BCR | |
| SCHEMBL19361169 | 0.83 | SMPD3 (0.35) | TRPV3CREBBPCDK5CDK5R1NPC1 | |
| SCHEMBL19670242 | 0.83 | SLC27A1 (0.35) | TRPV3NPC1RAB9ACARM1PRMT6 | |
| SCHEMBL19670251 | 0.82 | MLLT1 (0.39) | TRPV3CREBBPNPC1RAB9AABL1 | |
| SCHEMBL19670429 | 0.80 | BRAF (0.40) | CREBBPNPC1RAB9ACCR3 | |
| SCHEMBL19670228 | 0.79 | NPC1 (0.38) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |