Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670241 | 0.88 | GRM5 (0.38) | USP30GRM5PDK1PDK2PDK3 | |
| SCHEMBL19670252 | 0.88 | THRB (0.38) | USP30CYP1A2CYP3A4MAPK1BRD4 | |
| SCHEMBL19670392 | 0.87 | GRM5 (0.38) | USP30GRM5GPR6BRD4PDK1 | |
| SCHEMBL19670389 | 0.87 | ROCK2 (0.35) | TSHRMEN1KMT2AMTOR | |
| SCHEMBL19670257 | 0.86 | HPGDS (0.38) | MAPK1DYRK1AHPGDHSD17B10 | |
| SCHEMBL16775985 | 0.84 | GRM5 (0.38) | USP30CLK4ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL19670172 | 0.84 | ADORA2A (0.37) | USP30PDK1PDK2PDK3PDK4 | |
| SCHEMBL17618481 | 0.83 | GPR6 (0.40) | KCNH2TNIKUSP30CLK4ALDH1A1 | |
| SCHEMBL19670388 | 0.82 | CACNA1G (0.46) | BRAF | |
| SCHEMBL19670593 | 0.81 | JAK1 (0.38) | USP30BRD4PDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |