Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.33 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19669985 | 0.88 | KARS1 (0.43) | CARM1PRMT6PRMT8JAK2CAMK2D | |
| SCHEMBL19670263 | 0.88 | DHFR (0.37) | CARM1PRMT6PRMT8JAK2CAMK2D | |
| SCHEMBL19670258 | 0.87 | KCNH2 (0.37) | MTORTSHRMEN1KMT2A | |
| SCHEMBL19670257 | 0.86 | HPGDS (0.38) | MAPK14MAPT | |
| SCHEMBL16775987 | 0.85 | KARS1 (0.36) | ROCK2ROCK1CARM1PRMT6PRMT8 | |
| SCHEMBL19670432 | 0.84 | TRPV3 (0.34) | CARM1PRMT6PRMT8JAK2MTOR | |
| SCHEMBL17618487 | 0.84 | CARM1 (0.38) | ROCK2ROCK1CARM1PRMT6PRMT8 | |
| SCHEMBL19670393 | 0.82 | ABL1 (0.42) | JAK2CAMK2DTRPV3ABL1BCR | |
| SCHEMBL19670242 | 0.80 | SLC27A1 (0.35) | CARM1PRMT6PRMT8POLQTRPV3 | |
| SCHEMBL19670575 | 0.79 | EGFR (0.32) | TRPV3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |