Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | SLC5A1 | P13866 | 9/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670385 | 0.89 | MPL (0.44) | SLC5A1GSK3BMAPK14IRAK4PIM1 | |
| SCHEMBL19670164 | 0.89 | GSK3B (0.40) | SLC5A1GSK3BMAPK14IRAK4PIM1 | |
| SCHEMBL19670428 | 0.89 | ABL1 (0.40) | HPGDSSLC5A1GSK3BMAPK14DYRK1A | |
| SCHEMBL19670258 | 0.86 | KCNH2 (0.37) | DYRK1AHPGDMAPK1HSD17B10 | |
| SCHEMBL19670389 | 0.86 | ROCK2 (0.35) | MAPK14MAPT | |
| SCHEMBL17618476 | 0.84 | ABL1 (0.39) | HPGDSSLC5A1GSK3BMAPK14DYRK1A | |
| SCHEMBL19670589 | 0.84 | HTR2C (0.42) | — | |
| SCHEMBL19670590 | 0.82 | IRAK4 (0.41) | SLC5A1IRAK4PIM1 | |
| SCHEMBL19670238 | 0.82 | TRPA1 (0.38) | KDM4EHPGDMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL19670386 | 0.80 | CACNA1H (0.37) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |