Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365753 | 0.85 | CA12 (0.41) | KMOCTSKKCNH2CA12CA1 | |
| SCHEMBL19670450 | 0.85 | MEN1 (0.41) | PIK3CDPIK3CAPIK3CGCA12CA1 | |
| SCHEMBL19670398 | 0.84 | CTSK (0.38) | KMOCTSKKCNH2PIK3CDPIK3CA | |
| SCHEMBL19670322 | 0.81 | MAPK1 (0.38) | KMOSCN9AALDH1A1 | |
| SCHEMBL19670534 | 0.80 | DGAT2 (0.41) | KMOPIK3CDPIK3CAPIK3CGEGFR | |
| SCHEMBL19706034 | 0.73 | ALDH1A1 (0.39) | KMOPIK3CDPIK3CAPIK3CGADORA2A | |
| SCHEMBL19365828 | 0.73 | CA12 (0.46) | KMOCTSKKCNH2PIK3CDPIK3CA | |
| SCHEMBL19670382 | 0.73 | NPY5R (0.42) | PIK3CDPIK3CAPIK3CGCA12CA1 | |
| SCHEMBL19365619 | 0.72 | KMO (0.37) | KMOPIK3CDPIK3CAPIK3CGCA2 | |
| SCHEMBL19365558 | 0.70 | KDR (0.40) | KMOPIK3CDPIK3CAPIK3CGADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |