SCHEMBL1985195

SCHEMBL1985195

O=C(O)C1Cc2cc(F)c(F)c(O)c2N(C2CC2)C1=O

nearest known ligand 0.31

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
FFAR4 Q5NUL3 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10485479 0.84 FFAR4 (0.31) FFAR4
SCHEMBL8668032 0.79 MEN1 (0.33) MEN1KMT2AFFAR4
SCHEMBL10785290 0.78 MAOA (0.38)
SCHEMBL8817061 0.74 HTR2A (0.34) MEN1KMT2AFFAR4
SCHEMBL7024322 0.73 DRD2 (0.33) MEN1KMT2A
SCHEMBL6052739 0.72 KEAP1 (0.35)
SCHEMBL10558051 0.70 KDM4E (0.36)
SCHEMBL10556130 0.69 ACKR3 (0.30)
Hydrochloric Acid SCHEMBL4469284 0.69 KCNH2 (0.35) MEN1KMT2A
SCHEMBL4909217 0.69 ALDH1A1 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1767536-B1 QUINOLONECARBOXYLIC ACID COMPOUNDS, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF INST MED BIOTECHNOLOGY CAMS (CN) 2011-06-29 EP disclosed
US-7759362-B2 Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof INSTITUT OF MEDICINAL BIOTECHNOLOGY CHINESE ACADEMY OF MEDICAL SCIENCES (CN) 2010-07-20 US disclosed
US-20070219231-A1 Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof XINCHANG PHARMACEUTICAL FACTORY, ZHEJIANG MEDICINE CO. LTD. (CN) 2007-09-20 US disclosed
EP-1767536-A1 QUINOLONE CARBOXYLIC ACID DERIVATIVES, THEREOF PREPARATION AND USAGE Institute of Medicinal Biotechnology, Chinese Acadamy of Medical Sciences (CN) 2007-03-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070219231-A1 Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof NQO2, ABCG2, DHX15 MEN1 2734/4885KMT2A 3454/4885FFAR4 500/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.