Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8817061 | 0.89 | HTR2A (0.34) | MEN1KMT2AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL4909217 | 0.82 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL1985195 | 0.79 | MEN1 (0.31) | MEN1KMT2AFFAR4 | |
| SCHEMBL6052739 | 0.77 | KEAP1 (0.35) | DUSP3 | |
| SCHEMBL10485479 | 0.76 | FFAR4 (0.31) | FFAR4 | |
| SCHEMBL10785290 | 0.72 | MAOA (0.38) | TSHRALDH1A1KDM4ELMNACYP1A2 | |
| SCHEMBL7024322 | 0.67 | DRD2 (0.33) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL18091502 | 0.67 | KDM4E (0.45) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL8775559 | 0.66 | TOP2A (0.35) | TSHRTOP2APOLB | |
| SCHEMBL10558051 | 0.63 | KDM4E (0.36) | ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5783708-A | HEXAHYDROISOINDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-07-21 | — | — | US | disclosed |
| US-5391763-A | 3-aza-bicyclo[3.1.0]hexanes which are intermediates for anti-bacterial azabicyclo quinolone carboxylic acids | PFIZER INC. (US) | 1995-02-21 | — | — | US | disclosed |
| EP-0297858-A2 | Bridged-diazabicycloalkyl quinolone carboxylic acids and esters | PFIZER INC. (US) | 1989-01-04 | — | — | EP | disclosed |