SCHEMBL19923447

SCHEMBL19923447

CC1C(=O)N(C)C(=O)N1[Si](c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.34
TSHR P16473 2/20 0.34
BRD4 O60885 3/20 0.33
LOX P28300 1/20 0.33
LOXL3 P58215 1/20 0.33
LOXL4 Q96JB6 1/20 0.33
LOXL2 Q9Y4K0 1/20 0.33
MEN1 O00255 2/20 0.33
KDM4C Q9H3R0 1/20 0.33
MAPT P10636 3/20 0.33
ALDH1A1 P00352 2/20 0.33
GAA P10253 1/20 0.33
HSD17B10 Q99714 1/20 0.33
CCL2 P13500 1/20 0.33
GRM4 Q14833 1/20 0.32
ADORA3 P0DMS8 1/20 0.32
ADORA2A P29274 1/20 0.32
ADORA1 P30542 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19923746 0.83 GRM4 (0.35) LOXLOXL3LOXL4LOXL2GRM4
SCHEMBL5192164 0.73 MAOA (0.41) KMT2ATSHRLOXLOXL3LOXL4
SCHEMBL19923424 0.72 TSHR (0.34) KMT2ATSHRLOXLOXL3LOXL4
SCHEMBL19923518 0.71 MAPT (0.33) KMT2AMEN1MAPTALDH1A1GAA
SCHEMBL19923679 0.68 LOX (0.39) KMT2ALOXLOXL3LOXL4LOXL2
SCHEMBL19923480 0.67 ALDH1A1 (0.32) MAPTALDH1A1
SCHEMBL19923733 0.67 PDE4B (0.30)
SCHEMBL19923702 0.67 CES2 (0.34) ALDH1A1HSD17B10ADORA3MAPK1
SCHEMBL19923550 0.67 GRM4 (0.47) KMT2ATSHRBRD4LOXLOXL3
SCHEMBL19923602 0.66 SMO (0.37) KMT2AMEN1ADORA3NPSR1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10899718-B2 Polymers functionalized with N-protected hydantoin compounds BRIDGESTONE CORPORATION (JP) 2021-01-26 US claimed
US-20180065935-A1 POLYMERS FUNCTIONALIZED WITH N-PROTECTED HYDANTOIN COMPOUNDS BRIDGESTONE CORPORATION (JP) 2018-03-08 US claimed
US-10899718-B2 Polymers functionalized with N-protected hydantoin compounds BRIDGESTONE CORPORATION (JP) 2021-01-26 US disclosed
US-20180065935-A1 POLYMERS FUNCTIONALIZED WITH N-PROTECTED HYDANTOIN COMPOUNDS BRIDGESTONE CORPORATION (JP) 2018-03-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180065935-A1 POLYMERS FUNCTIONALIZED WITH N-PROTECTED HYDANTOIN COMPOUNDS PARG, HNMT, PARN KMT2A 1080/4885TSHR 4786/4885BRD4 391/4885
US-10899718-B2 Polymers functionalized with N-protected hydantoin compounds HNMT, PARG, PAM KMT2A 999/4885TSHR 4794/4885BRD4 490/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.