Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 4/20 | 0.41 |
| ▸ | METAP1 | P53582 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8412082 | 0.86 | METAP2 (0.30) | METAP2METAP1 | |
| SCHEMBL110807 | 0.85 | ALOX15 (0.42) | METAP2METAP1CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL110808 | 0.85 | ALOX15 (0.42) | METAP2METAP1CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL12655937 | 0.85 | ALOX15 (0.42) | METAP2METAP1CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL12438531 | 0.85 | ALOX15 (0.42) | METAP2METAP1CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL110806 | 0.85 | ALOX15 (0.42) | METAP2METAP1CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL16574584 | 0.84 | KIF11 (0.40) | METAP2METAP1ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8853649 | 0.83 | ALOX15 (0.41) | METAP2METAP1CYP2C9CYP2C19CYP2D6 | |
| Hydrochloric Acid SCHEMBL1564997 | 0.83 | ALOX15 (0.41) | METAP2METAP1CYP2C9CYP2C19CYP2D6 | |
| Hydrochloric Acid SCHEMBL8853645 | 0.83 | ALOX15 (0.41) | METAP2METAP1CYP2C9CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12037358-B2 | Compositions comprising reversibly modified oligonucleotides and uses thereof | DICERNA PHARMACEUTICALS, INC. (US) | 2024-07-16 | — | — | US | disclosed |
| US-12037358-B2 | Compositions comprising reversibly modified oligonucleotides and uses thereof | DICERNA PHARMACEUTICALS, INC. (US) | 2024-07-16 | — | — | US | disclosed |
| EP-3503730-B1 | COMPOSITIONS COMPRISING REVERSIBLY MODIFIED OLIGONUCLEOTIDES AND USES THEREOF | DICERNA PHARMACEUTICALS INC (US) | 2023-09-27 | — | — | EP | disclosed |
| US-20190177355-A1 | COMPOSITIONS COMPRISING REVERSIBLY MODIFIED OLIGONUCLEOTIDES AND USES THEREOF | NOVO NORDISK A/S (DK) | 2019-06-13 | — | — | US | disclosed |
| WO-2018039364-A1 | COMPOSITIONS COMPRISING REVERSIBLY MODIFIED OLIGONUCLEOTIDES AND USES THEREOF | DICERNA PHARMACEUTICALS, INC. (US) | 2018-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190177355-A1 | COMPOSITIONS COMPRISING REVERSIBLY MODIFIED OLIGONUCLEOTIDES AND USES THEREOF | GSS, GSR, RNMT | METAP2 306/4885METAP1 401/4885CYP2C9 3232/4885 |
| US-12037358-B2 | Compositions comprising reversibly modified oligonucleotides and uses thereof | GSS, GSR, RNMT | METAP2 306/4885METAP1 401/4885CYP2C9 3232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.