Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | METAP2 | P50579 | 5/20 | 0.39 |
| ▸ | METAP1 | P53582 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CAD | P27708 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12655937 | 1.00 | ALOX15 (0.42) | ALOX15ALDH1A1METAP2METAP1LMNA | |
| SCHEMBL110808 | 1.00 | ALOX15 (0.42) | ALOX15ALDH1A1METAP2METAP1LMNA | |
| SCHEMBL110806 | 1.00 | ALOX15 (0.42) | ALOX15ALDH1A1METAP2METAP1LMNA | |
| SCHEMBL110807 | 1.00 | ALOX15 (0.42) | ALOX15ALDH1A1METAP2METAP1LMNA | |
| Hydrochloric Acid SCHEMBL8853654 | 0.98 | ALOX15 (0.41) | ALOX15ALDH1A1METAP2METAP1LMNA | |
| Hydrochloric Acid SCHEMBL1564997 | 0.98 | ALOX15 (0.41) | ALOX15ALDH1A1METAP2METAP1LMNA | |
| Hydrochloric Acid SCHEMBL8853645 | 0.98 | ALOX15 (0.41) | ALOX15ALDH1A1METAP2METAP1LMNA | |
| Hydrochloric Acid SCHEMBL1564995 | 0.98 | ALOX15 (0.41) | ALOX15ALDH1A1METAP2METAP1LMNA | |
| Hydrochloric Acid SCHEMBL16798420 | 0.98 | ALOX15 (0.41) | ALOX15ALDH1A1METAP2METAP1LMNA | |
| Hydrochloric Acid SCHEMBL8853649 | 0.98 | ALOX15 (0.41) | ALOX15ALDH1A1METAP2METAP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12064410-B2 | Compositions and methods for stimulating ventilatory and/or respiratory | CASE WESTERN RESERVE UNIVERSITY (US) | 2024-08-20 | — | — | US | claimed |
| WO-2025123013-A1 | COMPOSITIONS FOR TREATING ADDICTION, DEPENDENCE, WITHDRAWAL, AND/OR OPIOID INDUCED HYPERALGESIA | CASE WESTERN RESERVE UNIVERSITY (US) | 2025-06-12 | — | — | WO | disclosed |
| US-20250009706-A1 | COMPOSITIONS AND METHODS FOR TREATING OPIOID DEPENDENCE AND WITHDRAWAL | CASE WESTERN RESERVE UNIVERSITY | 2025-01-09 | — | — | US | disclosed |
| US-12083089-B2 | Compositions and methods for stimulating ventilatory and/or respiratory drive | CASE WESTERN RESERVE UNIVERSITY (US) | 2024-09-10 | — | — | US | disclosed |
| US-12064410-B2 | Compositions and methods for stimulating ventilatory and/or respiratory | CASE WESTERN RESERVE UNIVERSITY (US) | 2024-08-20 | — | — | US | disclosed |
| EP-4373484-A1 | COMPOSITIONS AND METHODS FOR TREATING OPIOID DEPENDENCE AND WITHDRAWAL | CASE WESTERN RESERVE UNIVERSITY (US) | 2024-05-29 | — | — | EP | disclosed |
| US-20240139140-A9 | COMPOSITIONS AND METHODS FOR STIMULATING VENTILATORY AND/OR RESPIRATORY DRIVE | CASE WESTERN RESERVE UNIVERSITY | 2024-05-02 | — | — | US | disclosed |
| WO-2023003810-A1 | COMPOSITIONS AND METHODS FOR TREATING OPIOID DEPENDENCE AND WITHDRAWAL | CASE WESTERN RESERVE UNIVERSITY (US) | 2023-01-26 | — | — | WO | disclosed |
| US-20220273604-A1 | COMPOSITIONS AND METHODS FOR STIMULATING VENTILATORY AND/OR RESPIRATORY DRIVE | UNIV CASE WESTERN RESERVE (US) | 2022-09-01 | — | — | US | disclosed |
| US-9040261-B2 | Compounds as L-cystine crystallization inhibitors and uses thereof | NEW YORK UNIVERSITY (US) | 2015-05-26 | — | — | US | disclosed |
| US-9040261-B2 | Compounds as L-cystine crystallization inhibitors and uses thereof | NEW YORK UNIVERSITY (US) | 2015-05-26 | — | — | US | disclosed |
| US-8450089-B2 | Compounds as L-cystine crystallization inhibitors and uses thereof | NEW YORK UNIVERSITY (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450089-B2 | Compounds as L-cystine crystallization inhibitors and uses thereof | NEW YORK UNIVERSITY (US) | 2013-05-28 | — | — | US | disclosed |
| US-20110177173-A1 | COMPOUNDS AS L-CYSTINE CRYSTALLIZATION INHIBITORS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-07-21 | — | — | US | disclosed |
| US-20110177173-A1 | COMPOUNDS AS L-CYSTINE CRYSTALLIZATION INHIBITORS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-07-21 | — | — | US | disclosed |
| WO-2011062640-A1 | COMPOUNDS AS L-CYSTINE CRYSTALLIZATION INHIBITORS AND USES THEREOF | NEW YORK UNIVERSITY (US) | 2011-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12083089-B2 | Compositions and methods for stimulating ventilatory and/or respiratory drive | OPRM1, OPRK1, OPRD1 | ALOX15 1043/4885ALDH1A1 2591/4885METAP2 1728/4885 |
| US-20220273604-A1 | COMPOSITIONS AND METHODS FOR STIMULATING VENTILATORY AND/OR RESPIRATORY DRIVE | OPRM1, OPRK1, OPRD1 | ALOX15 1043/4885ALDH1A1 2591/4885METAP2 1728/4885 |
| US-12064410-B2 | Compositions and methods for stimulating ventilatory and/or respiratory | CTH, SLC25A20, CRH | ALOX15 1121/4885ALDH1A1 3758/4885METAP2 1212/4885 |
| US-20110177173-A1 | COMPOUNDS AS L-CYSTINE CRYSTALLIZATION INHIBITORS AND USES THEREOF | GLS, PKD1, CLIC1 | ALOX15 619/4885ALDH1A1 1636/4885METAP2 600/4885 |
| US-20250009706-A1 | COMPOSITIONS AND METHODS FOR TREATING OPIOID DEPENDENCE AND WITHDRAWAL | OPRM1, OPRK1, OPRD1 | ALOX15 1219/4885ALDH1A1 630/4885METAP2 427/4885 |
| US-20240139140-A9 | COMPOSITIONS AND METHODS FOR STIMULATING VENTILATORY AND/OR RESPIRATORY DRIVE | OPRM1, OPRK1, OPRD1 | ALOX15 1043/4885ALDH1A1 2591/4885METAP2 1728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.