Sugi Predict

Sugi Predict / Compounds / SCHEMBL1993328

SCHEMBL1993328

SCHEMBL1993328

COc1ccc2nc(C(=O)O)ccc2c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 7/20 0.57
▸ NCF1 P14598 1/20 0.56
▸ NQO1 P15559 1/20 0.53
▸ HDAC3 O15379 1/20 0.52
▸ HDAC4 P56524 1/20 0.52
▸ HDAC1 Q13547 1/20 0.52
▸ HDAC7 Q8WUI4 1/20 0.52
▸ HDAC2 Q92769 1/20 0.52
▸ HDAC10 Q969S8 1/20 0.52
▸ HDAC11 Q96DB2 1/20 0.52
▸ HDAC8 Q9BY41 1/20 0.52
▸ HDAC6 Q9UBN7 1/20 0.52
▸ HDAC9 Q9UKV0 1/20 0.52
▸ HDAC5 Q9UQL6 1/20 0.52
▸ MGAM O43451 1/20 0.51
▸ ALDH1A1 P00352 5/20 0.51
▸ HPGD P15428 4/20 0.51
▸ POLB P06746 2/20 0.51
▸ HSD17B10 Q99714 1/20 0.51
▸ CNR2 P34972 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL755482 0.88 KDM4E (0.54) KDM4EMGAMALDH1A1HPGDPOLB
SCHEMBL23751547 0.87 HDAC8 (0.56) KDM4ENCF1NQO1HDAC3HDAC4
SCHEMBL6827783 0.85 KDM4E (0.60) KDM4ENCF1NQO1HDAC3HDAC4
SCHEMBL7342388 0.85 HDAC8 (0.55) KDM4ENCF1NQO1HDAC3HDAC4
SCHEMBL29923914 0.83 KDM4E (0.55) KDM4ENCF1MGAMALDH1A1HPGD
SCHEMBL27462478 0.82 CNR2 (0.42) KDM4ENCF1NQO1HDAC3HDAC4
SCHEMBL23761146 0.81 NCF1 (0.54) KDM4ENCF1NQO1HDAC3HDAC4
SCHEMBL2652525 0.81 CLK1 (0.51) KDM4ENCF1NQO1HDAC3HDAC4
SCHEMBL28434347 0.80 KDM4E (0.65) KDM4ENCF1HDAC3HDAC4HDAC1
SCHEMBL31403537 0.80 HPGDS (0.55) KDM4ENCF1ALDH1A1HPGDPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11697636-B2 Substituted benzamides HOFFMANN-LA ROCHE INC. (US) 2023-07-11 — — US claimed
US-20210061760-A1 SUBSTITUTED BENZAMIDES HOFFMANN LA ROCHE (US) 2021-03-04 — — US claimed
CN-108314647-B Preparation method of quinoline-2-formic acid and quinoline-2-formic acid derivative 华中科技大学 2020-06-26 — — CN claimed
US-20200048194-A1 SUBSTITUTED BENZAMIDES F. HOFFMANN-LA ROCHE AG (CH) 2020-02-13 — — US claimed
CN-108314647-A A kind of preparation method of quinoline -2- formic acid and quinoline -2- formic acid derivates 华中科技大学 2018-07-24 — — CN claimed
EP-3187490-A1 SUBSTITUTED BENZAMIDE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2017-07-05 — — EP claimed
CN-105254623-A SUBSTITUTED BENZAMIDES HOFFMANN LA ROCHE 2016-01-20 — — CN claimed
EP-2516392-A1 SUBSTITUTED BENZAMIDE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2012-10-31 — — EP claimed
US-12637468-B2 Substituted [1,2,4]triazolo[4,3-b]pyridazines as GABAA receptor modulators Shanghai Simr Biotechnology Co., Ltd. (CN) 2026-05-26 — — US disclosed
EP-4079734-B1 TRIAZOLOPYRIDAZINE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF SHANGHAI SIMR BIOTECHNOLOGY CO LTD (CN) 2025-09-17 — — EP disclosed
CN-118812631-A Fibroblast activator protein ligand for targeted delivery applications 菲洛谢姆股份公司 2024-10-22 — — CN disclosed
CN-115335370-B Fibroblast activator protein ligand for targeted delivery applications 菲洛谢姆股份公司 2024-08-23 — — CN disclosed
US-12050224-B2 Compounds useful as near-infrared fluorescent probes selectively binding to tau aggregates and method of preparing the same KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2024-07-30 — — US disclosed
WO-2024086804-A1 INDOLIZINE DERIVATIVES FOR TREATING CANCER SCORPION THERAPEUTICS, INC. (US) 2024-04-25 — — WO disclosed
US-5641785-A ANTIDEPRESSANTS, NERVOUS SYSTEM DISORDERS SYNTHELABO (FR) 1997-06-24 — — US disclosed
CN-1128763-A Oxazoloquinolinone derivatives, their preparation and their therapeutic use SYNTHELABO (FR) 1996-08-14 — — CN disclosed
EP-0699680-A1 Oxazoloquinolinone derivatives, their preparation and their use in therapy SYNTHELABO (FR) 1996-03-06 — — EP disclosed
US-4461896-A 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids NORWICH EATON PHARMACEUTICALS, INC. (US) 1984-07-24 — — US disclosed
US-4389403-A HYPOTENSIVE AGENTS BASF AKTIENGESELLSCHAFT (DE) 1983-06-21 — — US disclosed
EP-0037471-A1 1-Aroyl-2-phenylamino-2-imidazolines, their preparation and their pharmaceutical compositions BASF Aktiengesellschaft (DE) 1981-10-14 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12050224-B2 Compounds useful as near-infrared fluorescent probes selectively binding to tau aggregates and method of preparing the same MAPT, PSEN1, PSEN2 KDM4E 4798/4885NCF1 1700/4885NQO1 2397/4885
US-20210061760-A1 SUBSTITUTED BENZAMIDES TAAR1, TAAR5, NPY1R KDM4E 1864/4885NCF1 3829/4885NQO1 2538/4885
US-12637468-B2 Substituted [1,2,4]triazolo[4,3-b]pyridazines as GABAA receptor modulators GABRA6, GABRA1, GABRB1 KDM4E 3564/4885NCF1 2821/4885NQO1 2070/4885
US-20200048194-A1 SUBSTITUTED BENZAMIDES TAAR1, TAAR5, NPY1R KDM4E 1864/4885NCF1 3829/4885NQO1 2538/4885
US-11697636-B2 Substituted benzamides TAAR1, TAAR5, NPY1R KDM4E 1864/4885NCF1 3829/4885NQO1 2538/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.