SCHEMBL1994130

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1126928	0.94	MAPT (0.39)	MAPTPOLBHTR2AHTR2CSLC6A4
	SCHEMBL1126921	0.83	MAPT (0.37)	MAPTPOLBHTR2AHTR2CSLC6A4
	SCHEMBL1126883	0.83	SIGMAR1 (0.38)	MAPTPOLBHTR2AHTR2CSLC6A4
	SCHEMBL1989043	0.83	MAPT (0.38)	MAPTPOLBTP53KDM4E
	SCHEMBL1126468	0.82	TSHR (0.39)	MAPTHTR2AHTR2CSLC6A4LMNA
	SCHEMBL1999344	0.81	MAPT (0.41)	MAPTPOLBALDH1A1NPSR1
	SCHEMBL1126522	0.80	MAPT (0.37)	MAPTPOLBLMNATP53
	SCHEMBL1127171	0.80	POLB (0.42)	MAPTPOLBLMNAALDH1A1KDM4E
	SCHEMBL1126811	0.79	MAPT (0.36)	MAPTPOLBLMNATP53KDM4E
	SCHEMBL1990333	0.75	MAPKAPK2 (0.41)	MAPTALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.