Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Pantoprazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A known ✓ | P20648 | 14/20 | 0.52 |
| ▸ | ATP4B known ✓ | P51164 | 14/20 | 0.52 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.52 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | FASN | P49327 | 1/20 | 0.52 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.52 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.52 |
| ▸ | ATP1A1 | P05023 | 7/20 | 0.44 |
| ▸ | ATP1B1 | P05026 | 7/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pantoprazole SCHEMBL636218 | 1.00 | ATP4A (0.52) | ATP4AATP4BCYP2C9KDM4ESLC22A2 | |
| Pantoprazole SCHEMBL4640983 | 1.00 | ATP4A (0.52) | ATP4AATP4BCYP2C9KDM4ESLC22A2 | |
| Pantoprazole SCHEMBL6262319 | 0.99 | ATP4A (0.53) | ATP4AATP4BCYP2C9KDM4ESLC22A2 | |
| Pantoprazole SCHEMBL3179774 | 0.99 | ATP4A (0.53) | ATP4AATP4BCYP2C9KDM4ESLC22A2 | |
| Pantoprazole SCHEMBL4199906 | 0.99 | ATP4A (0.53) | ATP4AATP4BCYP2C9KDM4ESLC22A2 | |
| Pantoprazole SCHEMBL1716777 | 0.99 | ATP4A (0.53) | ATP4AATP4BCYP2C9KDM4ESLC22A2 | |
| Pantoprazole SCHEMBL1477291 | 0.98 | ATP4A (0.52) | ATP4AATP4BCYP2C9KDM4ESLC22A2 | |
| Pantoprazole SCHEMBL21986309 | 0.98 | ATP4A (0.52) | ATP4AATP4BCYP2C9KDM4ESLC22A2 | |
| Pantoprazole SCHEMBL1476428 | 0.98 | ATP4A (0.52) | ATP4AATP4BCYP2C9KDM4ESLC22A2 | |
| Pantoprazole SCHEMBL1476069 | 0.98 | ATP4A (0.52) | ATP4AATP4BCYP2C9KDM4ESLC22A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012171540-A1 | SUPPOSITORY COMPRISING PANTOPRAZOLE COMPRISED IN PELLETS WITH A CELLULOSE CORE | BENE-ARZNEIMITTEL GMBH (DE) | 2012-12-20 | — | — | WO | disclosed |
| US-20120301543-A1 | SUPPOSITORY COMPRISING PANTOPRAZOLE | BENEARZNEIMITTEL GMBH (DE) | 2012-11-29 | — | — | US | disclosed |
| EP-2512445-A1 | SUPPOSITORY COMPRISING PANTOPRAZOLE | Bene-Arnzeimittel GmbH (DE) | 2012-10-24 | — | — | EP | disclosed |
| EP-2338477-A1 | Suppository comprising pantoprazole | bene-Arzneimittel GmbH (DE) | 2011-06-29 | — | — | EP | disclosed |
| WO-2011072861-A1 | SUPPOSITORY COMPRISING PANTOPRAZOLE | BENE-ARZNEIMITTEL GMBH (DE) | 2011-06-23 | — | — | WO | disclosed |
| EP-1527066-A1 | SALT OF (S)-PANTOPRAZOLE AND ITS HYDRATES | ALTANA Pharma AG (DE) | 2005-05-04 | — | — | EP | disclosed |
| WO-2005012289-A1 | NOVEL SALT OF (R) - PANTOPRAZOLE | ALTANA PHARMA AG (DE) | 2005-02-10 | — | — | WO | disclosed |
| WO-2004013126-A1 | SALT OF (S)-PANTOPRAZOLE AND ITS HYDRATES | ALTANA PHARMA AG (DE) | 2004-02-12 | — | — | WO | disclosed |