Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 3/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.34 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.34 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.34 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976727 | 0.93 | GSK3B (0.36) | PTGESHDAC6MEN1KMT2AGSK3B | |
| SCHEMBL19976798 | 0.91 | PTGES (0.36) | PTGESHDAC6MEN1KMT2ACYP3A4 | |
| SCHEMBL19976944 | 0.84 | MAPK1 (0.36) | KMT2AGSK3BMAPK1MAP2K4MAPK6 | |
| SCHEMBL19976928 | 0.81 | CTNNB1 (0.37) | PTGESKMT2AMAPK1ALDH1A1HTT | |
| SCHEMBL17088632 | 0.78 | GPR139 (0.37) | HDAC6MAPK1IDO1KCNH2ALDH1A1 | |
| SCHEMBL19976851 | 0.77 | POLB (0.35) | KMT2AMAPK1MAP2K4MAPK6NPSR1 | |
| SCHEMBL19362702 | 0.77 | RAB9A (0.39) | MEN1KMT2AMAPK1NPSR1IDO1 | |
| SCHEMBL19362781 | 0.77 | RAB9A (0.39) | MEN1KMT2AMAPK1NPSR1IDO1 | |
| SCHEMBL19976829 | 0.77 | HDAC6 (0.51) | HDAC6GSK3BMAPK1MAP2K4MAPK6 | |
| SCHEMBL16771509 | 0.75 | MEN1 (0.33) | MEN1KMT2ACYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |