Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 5/20 | 0.37 |
| ▸ | TCF7L2 | Q9NQB0 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | RHOC | P08134 | 2/20 | 0.34 |
| ▸ | RHOA | P61586 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976944 | 0.91 | MAPK1 (0.36) | LMNAKDM4EALDH1A1TP53MAPK1 | |
| SCHEMBL19976833 | 0.91 | HPGD (0.41) | LMNAKDM4EALDH1A1TP53GAA | |
| SCHEMBL19976798 | 0.91 | PTGES (0.36) | LMNAKDM4EALDH1A1TP53GAA | |
| SCHEMBL19976803 | 0.89 | MAPK1 (0.38) | LMNAKDM4EALDH1A1TP53GAA | |
| SCHEMBL19976851 | 0.85 | POLB (0.35) | CTNNB1TCF7L2LMNAKDM4EALDH1A1 | |
| SCHEMBL18558300 | 0.84 | NPC1 (0.46) | KDM4EALDH1A1GAAKMT2A | |
| SCHEMBL19976806 | 0.83 | HPGD (0.51) | LMNAKDM4EALDH1A1TP53GAA | |
| SCHEMBL19976796 | 0.82 | MAPT (0.43) | KDM4EALDH1A1GAAMAPK1HPGD | |
| SCHEMBL19976727 | 0.82 | GSK3B (0.36) | LMNATP53MAPK1PTGESHTT | |
| SCHEMBL19976770 | 0.81 | MAPK1 (0.38) | ALDH1A1MAPK1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |