Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 10/20 | 0.40 |
| ▸ | TYR | P14679 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | ICMT | O60725 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CTRC | Q99895 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20344678 | 0.79 | ESR1 (0.38) | SLC6A4ALOX5 | |
| SCHEMBL24497563 | 0.78 | CYP19A1 (0.41) | MPOTYRSLC6A4 | |
| SCHEMBL19980344 | 0.78 | NPY2R (0.40) | CYP3A4CTRC | |
| SCHEMBL19980436 | 0.72 | HTR2C (0.41) | MEN1TP53MAPTHTTKMT2A | |
| SCHEMBL13349755 | 0.71 | TYR (0.50) | MPOTYRALOX15MEN1TP53 | |
| SCHEMBL20344640 | 0.71 | ALOX15 (0.42) | MPOTYRALOX15MEN1TP53 | |
| SCHEMBL24094045 | 0.71 | ALDH1A1 (0.30) | — | |
| SCHEMBL7459469 | 0.70 | TYR (0.46) | MPOTYRSLC6A4ICMTALOX15 | |
| SCHEMBL24094025 | 0.70 | ICMT (0.31) | ICMT | |
| SCHEMBL22176382 | 0.70 | TYR (0.48) | MPOTYRGHSRALOX15MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3375780-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-06-03 | — | — | EP | disclosed |
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |