SCHEMBL19983743

SCHEMBL19983743

CNCc1cn(Sc2cccnc2)c2cc(Nc3cc(OC)c(Cl)cc3Cl)ccc12

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SRC P12931 13/20 0.40
GAA P10253 1/20 0.36
PDE5A O76074 1/20 0.35
PGK1 P00558 1/20 0.35
FLT1 P17948 2/20 0.34
KDR P35968 2/20 0.34
EPHA2 P29317 1/20 0.34
EPHB4 P54760 1/20 0.34
SLC6A2 P23975 1/20 0.34
SLC6A4 P31645 1/20 0.34
PDGFRB P09619 1/20 0.34
KIT P10721 1/20 0.34
ALPL P05186 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19983883 0.91 HTR2C (0.32) FLT1KDREPHA2EPHB4SLC6A2
SCHEMBL19983733 0.86 SLC6A2 (0.37) SRCFLT1SLC6A2SLC6A4
SCHEMBL19984223 0.85 SLC6A2 (0.32) SLC6A2SLC6A4KIT
SCHEMBL19984171 0.85 POLB (0.37) SLC6A2
SCHEMBL19984135 0.84 BCL6 (0.40) SRCALPL
SCHEMBL19983840 0.84 LRRK2 (0.36)
SCHEMBL19983850 0.83 LRRK2 (0.40) SRCPDE5ASLC6A4
SCHEMBL19983736 0.83 MAPT (0.38) GAA
SCHEMBL19984087 0.83 SLC6A2 (0.34) SLC6A2SLC6A4
SCHEMBL19983844 0.82 ALDH1A1 (0.35) KIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3052484-B1 SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME DAE WOONG PHARMA (KR) 2018-03-21 EP disclosed