Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 11/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002171 | 0.84 | KMT2A (0.38) | HSD11B1OPRM1KMT2A | |
| SCHEMBL20003044 | 0.78 | RORC (0.40) | — | |
| SCHEMBL20002167 | 0.77 | KDM1A (0.40) | CHRM5CHRM3 | |
| SCHEMBL20002564 | 0.76 | NAMPT (0.41) | HSD11B1KMT2A | |
| SCHEMBL20003241 | 0.76 | RORC (0.41) | HSD11B1KMT2A | |
| SCHEMBL20002207 | 0.75 | RORC (0.45) | — | |
| SCHEMBL20002926 | 0.75 | RORC (0.43) | KCNH2OPRL1 | |
| SCHEMBL20002856 | 0.75 | RORC (0.42) | HSD11B1KMT2A | |
| SCHEMBL20002748 | 0.74 | RORC (0.39) | HSD11B1KMT2A | |
| SCHEMBL20003052 | 0.74 | HSD11B1 (0.38) | HSD11B1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |