Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 3/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002931 | 0.86 | PDK2 (0.39) | PDK2RORCDRD2DRD4DRD3 | |
| SCHEMBL20002917 | 0.82 | MEN1 (0.47) | KMT2AALDH1A1 | |
| SCHEMBL20002210 | 0.80 | RORC (0.44) | PDK2RORCDRD2DRD4DRD3 | |
| SCHEMBL20002956 | 0.80 | RORC (0.44) | PDK2RORCDRD2DRD4DRD3 | |
| SCHEMBL20002167 | 0.78 | KDM1A (0.40) | RORCLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL20002280 | 0.78 | TACR1 (0.40) | RORCDPP4DPP7HSD11B1 | |
| SCHEMBL20002286 | 0.77 | TACR1 (0.45) | RORC | |
| SCHEMBL20002564 | 0.77 | NAMPT (0.41) | HSD11B1LMNAKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4773698 | 0.77 | MEN1 (0.51) | KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL20002698 | 0.77 | HSD11B1 (0.47) | RORCHSD11B1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |