Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 8/20 | 0.55 |
| ▸ | MMP13 | P45452 | 6/20 | 0.41 |
| ▸ | MMP1 | P03956 | 4/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 3/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002922 | 0.89 | RORC (0.46) | RORCEPHX2GPR6 | |
| SCHEMBL20002566 | 0.79 | RORC (0.46) | RORCMMP13MMP1MMP2MMP3 | |
| SCHEMBL20002322 | 0.76 | PKM (0.60) | RORCEPHX2AKT1PIK3CAPKM | |
| SCHEMBL20002497 | 0.76 | RORC (0.44) | RORCGPR6 | |
| SCHEMBL20002921 | 0.75 | RORC (0.44) | RORCGPR6 | |
| SCHEMBL20002406 | 0.75 | RORC (0.42) | RORCEPHX2HTR2AHTR2CKCNH2 | |
| SCHEMBL20002866 | 0.74 | RORC (0.49) | RORCEPHX2GPR6HTR2AHTR2C | |
| SCHEMBL13890294 | 0.73 | EPHX2 (0.50) | EPHX2GPR6PKMHTR2AHTR2C | |
| SCHEMBL20003153 | 0.73 | RORC (0.41) | RORCEPHX2GPR6HTR2AHTR2C | |
| SCHEMBL20003009 | 0.73 | RORC (0.54) | RORCEPHX2GPR6HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |